Fujiwara Ikuko, Köster Sarah
Department of Materials Science and Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka-Cho, Nagaoka, Niigata, 940-2188 Japan.
Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.
Biophys Rev. 2024 Aug 27;16(5):521-523. doi: 10.1007/s12551-024-01218-1. eCollection 2024 Oct.
The cytoskeleton is the major mechanical unit of the cell and is essential for cellular processes such as motility, division, and contraction. It consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-along with passive cross-linkers and active motor proteins. This composite biological material determines the enormous viscoelastic adaptability of cells to varying mechanical demands. In the session entitled "Cell Motility, Cytoskeleton, and Motor Proteins" at the IUPAB 2024 Congress in Kyoto, Japan, we elucidated specific examples of cell mechanics and dynamics from a physical point of view, including different length scales from molecular to cellular, as well as in vitro reconstituted systems and cellular systems.
细胞骨架是细胞的主要机械单元，对于诸如运动、分裂和收缩等细胞过程至关重要。它由三种生物聚合物组成——肌动蛋白丝、微管和中间丝——以及被动交联剂和活性运动蛋白。这种复合生物材料决定了细胞对不同机械需求的巨大粘弹性适应性。在日本京都举行的2024年国际纯粹与应用生物物理联合会（IUPAB）大会上，在题为“细胞运动、细胞骨架和运动蛋白”的会议中，我们从物理角度阐明了细胞力学和动力学的具体例子，包括从分子到细胞的不同长度尺度，以及体外重组系统和细胞系统。
