接受棘白菌素预防治疗的青少年急性髓系白血病患者发生感染
Infection in Teen With Acute Myeloid Leukemia Receiving Echinocandin Prophylaxis.
作者信息
Killingsworth Jordan, Boren Rachel, Sheth Rachna, Chang Michael L
机构信息
Department of Internal Medicine-Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.
Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.
出版信息
Case Rep Infect Dis. 2024 Nov 20;2024:4459447. doi: 10.1155/crdi/4459447. eCollection 2024.
Abstract
We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.
摘要
我们报告了一例15岁的难治性复发性急性髓系白血病（AML）患者，该患者存在严重的长期中性粒细胞减少症，在接受棘白菌素预防侵袭性真菌病期间发生了播散性侵袭性感染。由于担心细胞色素P450（CYP）药物相互作用，最初避免使用常用于预防的唑类抗真菌疗法。在等待中性粒细胞恢复期间，联合使用脂质体两性霉素B、伏立康唑及辅助性粒细胞输注进行治疗取得了成功。
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