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本文引用的文献

1
Invasive Fungal Infections and Targeted Therapies in Hematological Malignancies.血液系统恶性肿瘤中的侵袭性真菌感染与靶向治疗
J Fungi (Basel). 2021 Dec 10;7(12):1058. doi: 10.3390/jof7121058.
2
Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM.全球罕见酵母感染诊断与管理指南：由欧洲癌症研究与治疗组织（ECMM）联合国际临床微生物学与感染病学会（ISHAM）和美国微生物学会（ASM）共同发起。
Lancet Infect Dis. 2021 Dec;21(12):e375-e386. doi: 10.1016/S1473-3099(21)00203-6. Epub 2021 Aug 19.
3
Invasive Infections: An Emerging Threat to Immunocompromised Patients.侵袭性感染：对免疫功能低下患者的新威胁。
Pathogens. 2020 Nov 7;9(11):922. doi: 10.3390/pathogens9110922.
4
Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients.儿童恶性肿瘤患者和造血干细胞移植受者全身性抗真菌预防的临床实践指南。
J Clin Oncol. 2020 Sep 20;38(27):3205-3216. doi: 10.1200/JCO.20.00158. Epub 2020 May 27.
5
Epidemiology of invasive fungal infections in immunocompromised children; an Australian national 10-year review.免疫功能低下儿童侵袭性真菌感染的流行病学：澳大利亚全国 10 年回顾。
Pediatr Blood Cancer. 2019 Apr;66(4):e27564. doi: 10.1002/pbc.27564. Epub 2018 Dec 4.
6
Echinocandin prophylaxis in patients undergoing haematopoietic cell transplantation and other treatments for haematological malignancies.棘白菌素类预防用药在造血细胞移植及其他血液系统恶性肿瘤治疗中的应用。
J Antimicrob Chemother. 2018 Jan 1;73(suppl_1):i60-i72. doi: 10.1093/jac/dkx450.
7
Sequencing of Hot Spot 1 from Saprochaete capitata To Search for a Relationship to Reduced Echinocandin Susceptibility.对 Saprochaete capitata 的热点 1 进行测序以寻找与降低棘白菌素敏感性的关系。
Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01246-17. Print 2018 Feb.
8
Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction.粒细胞输注用于治疗中性粒细胞减少或中性粒细胞功能障碍患者的感染。
Cochrane Database Syst Rev. 2016 Apr 29;4(4):CD005339. doi: 10.1002/14651858.CD005339.pub2.
9
Saprochaete clavata invasive infection in a patient with severe aplastic anemia: Efficacy of voriconazole and liposomal amphotericin B with adjuvant granulocyte transfusions before neutrophil recovery following allogeneic bone marrow transplantation.一名重型再生障碍性贫血患者发生棒状腐皮壳菌侵袭性感染：异基因骨髓移植后中性粒细胞恢复前伏立康唑和脂质体两性霉素B联合辅助性粒细胞输注的疗效
Med Mycol Case Rep. 2016 Mar 8;11:21-3. doi: 10.1016/j.mmcr.2016.03.001. eCollection 2016 Mar.
10
Invasive Fungal Infections in Pediatric Acute Myelogenous Leukemia.儿童急性髓系白血病中的侵袭性真菌感染
Pediatr Infect Dis J. 2015 Nov;34(11):1262-4. doi: 10.1097/INF.0000000000000875.

接受棘白菌素预防治疗的青少年急性髓系白血病患者发生感染

Infection in Teen With Acute Myeloid Leukemia Receiving Echinocandin Prophylaxis.

作者信息

Killingsworth Jordan, Boren Rachel, Sheth Rachna, Chang Michael L

机构信息

Department of Internal Medicine-Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.

Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.

出版信息

Case Rep Infect Dis. 2024 Nov 20;2024:4459447. doi: 10.1155/crdi/4459447. eCollection 2024.

DOI:10.1155/crdi/4459447
PMID:39619279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11606694/
Abstract

We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.

摘要

我们报告了一例15岁的难治性复发性急性髓系白血病（AML）患者，该患者存在严重的长期中性粒细胞减少症，在接受棘白菌素预防侵袭性真菌病期间发生了播散性侵袭性感染。由于担心细胞色素P450（CYP）药物相互作用，最初避免使用常用于预防的唑类抗真菌疗法。在等待中性粒细胞恢复期间，联合使用脂质体两性霉素B、伏立康唑及辅助性粒细胞输注进行治疗取得了成功。