• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma.

作者信息

Dai Jingyao, Liu Su, Xie Yangyang, Wang Yixuan, Bian Xiyun, Yu Tian, Li Tiantian, Jia Linchuang, Zhao Zhigang, Liu Zhiqiang, Liu Xiaozhi

机构信息

Hepatobiliary Surgery Department, Air Force Medical Center, Beijing 100142, China.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

出版信息

Genes Dis. 2024 Apr 5;12(2):101288. doi: 10.1016/j.gendis.2024.101288. eCollection 2025 Mar.

DOI:10.1016/j.gendis.2024.101288
PMID:39619481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11605339/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa40/11605339/fdee81c96af4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa40/11605339/fdee81c96af4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa40/11605339/fdee81c96af4/gr1.jpg

相似文献

1
TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma.TULP4降解RYBP以增强胰腺导管腺癌的DNA损伤修复和化疗敏感性。
Genes Dis. 2024 Apr 5;12(2):101288. doi: 10.1016/j.gendis.2024.101288. eCollection 2025 Mar.
2
RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair.RYBP 是一种 K63 泛素链结合蛋白，可抑制同源重组修复。
Cell Rep. 2018 Jan 9;22(2):383-395. doi: 10.1016/j.celrep.2017.12.047.
3
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma.hsa_circ_0007919 通过与 FOXA1/TET1 结合诱导 LIG1 转录，增强 DNA 损伤反应，促进胰腺导管腺癌对吉西他滨的耐药性。
Mol Cancer. 2023 Dec 4;22(1):195. doi: 10.1186/s12943-023-01887-8.
4
Association of Germline Variants in Human DNA Damage Repair Genes and Response to Adjuvant Chemotherapy in Resected Pancreatic Ductal Adenocarcinoma.种系 DNA 损伤修复基因中的变异与可切除胰腺导管腺癌辅助化疗反应的相关性。
J Am Coll Surg. 2020 Nov;231(5):527-535.e14. doi: 10.1016/j.jamcollsurg.2020.06.019. Epub 2020 Jul 11.
5
RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo.RYBP表达与肝细胞癌（HCC）患者的更好生存率以及HCC细胞在体外和体内对化疗的反应性相关。
Oncotarget. 2014 Nov 30;5(22):11604-19. doi: 10.18632/oncotarget.2598.
6
RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity.RYBP 通过调节 ATM 活性使癌细胞对 PARP 抑制剂敏感。
Int J Mol Sci. 2022 Oct 4;23(19):11764. doi: 10.3390/ijms231911764.
7
The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma.胚系/体细胞 DNA 损伤修复基因突变可调节中国晚期胰腺导管腺癌患者的治疗反应。
J Transl Med. 2021 Jul 12;19(1):301. doi: 10.1186/s12967-021-02972-6.
8
H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma.H2A.Z过表达抑制胰腺导管腺癌的衰老和化疗敏感性。
Oncogene. 2021 Mar;40(11):2065-2080. doi: 10.1038/s41388-021-01664-1. Epub 2021 Feb 24.
9
Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment.精准设计纳米药物恢复吉西他滨化疗敏感性用于个体化胰腺导管腺癌治疗
Biomaterials. 2018 Mar;158:44-55. doi: 10.1016/j.biomaterials.2017.12.015. Epub 2017 Dec 20.
10
Targeting Defects in the Cellular DNA Damage Response for the Treatment of Pancreatic Ductal Adenocarcinoma.针对细胞 DNA 损伤反应缺陷的治疗策略用于胰腺导管腺癌。
Oncol Res Treat. 2018;41(10):619-625. doi: 10.1159/000493401. Epub 2018 Sep 28.

本文引用的文献

1
Inflammation and DNA damage: cause, effect or both.炎症与DNA损伤：原因、结果还是两者皆有。
Nat Rev Rheumatol. 2023 Apr;19(4):200-211. doi: 10.1038/s41584-022-00905-1. Epub 2023 Feb 7.
2
Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance.胰腺癌发病机制和治疗抵抗中的肿瘤微环境。
Annu Rev Pathol. 2023 Jan 24;18:123-148. doi: 10.1146/annurev-pathmechdis-031621-024600. Epub 2022 Sep 21.
3
Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance.RECQL4 家族在维持基因组完整性中的作用和调控。
Genes (Basel). 2021 Nov 29;12(12):1919. doi: 10.3390/genes12121919.
4
Current epidemiology of pancreatic cancer: Challenges and opportunities.胰腺癌的当前流行病学：挑战与机遇。
Chin J Cancer Res. 2020 Dec 31;32(6):705-719. doi: 10.21147/j.issn.1000-9604.2020.06.04.
5
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.巨噬细胞释放的嘧啶类物质抑制胰腺癌的吉西他滨治疗。
Cell Metab. 2019 Jun 4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28.