Sawan Hana M, Shroukh Wejdan, Abutaima Rana, Al Omari Shatha M, Abdel-Qader Derar H, Binsuwaidan Reem
Pharmaceutical Sciences Department, Faculty of Pharmacy, Zarqa University, Zqrqa, Jordan.
Faculty of Pharmacy, Middle East University, Amman, Jordan.
Infect Drug Resist. 2024 Nov 26;17:5203-5214. doi: 10.2147/IDR.S494714. eCollection 2024.
This study aimed to assess Jordanian pharmacists' knowledge of the human microbiome and the impact of their knowledge on their attitudes and practices toward antibiotics and probiotics.
A self-administered survey was designed after reviewing the literature. Participants' demographics were collected, and questions to evaluate pharmacists' knowledge, attitudes, and practices toward antibiotic and probiotic dispensing were asked. The data were analyzed using the Statistical Package for the Social Sciences V.26. Pearson correlations and one-way ANOVA were employed to calculate the significance of knowledge, attitudes, and practices. Statistical significance was considered at p < 0.05.
Of the 333 respondents, around 75% (n=250) had a high level of general knowledge regarding the human gut microbiome. Almost equal proportions of participants had either intermediate or high levels of knowledge about the role of gut bacteria in health (n=164, 49.2%) (n=166, 49.8%), respectively, while almost two-thirds had an intermediate level of knowledge of the role of gut bacteria in disease (n=197, 59.2%). More than half of the participants had a positive attitude toward antibiotics, probiotics, and the human microbiome (n=179, 53.8%), and the majority (n=239, 71.8%) had an intermediate level of practice with them. There was a significant positive correlation between pharmacists' general knowledge of the human microbiome and their positive attitudes (=0.306, p < 0.01) and practices (=0.331, p < 0.01) toward antibiotics and probiotics.
Study results raise the importance of interventional educational measures to promote healthcare professionals' knowledge of the human microbiome and their potential beneficence on pharmacists' attitudes and practices regarding antibiotics and probiotics dispensing. The results also denote the urgent need for probiotics' clinical guidelines to ensure practice uniformity.
本研究旨在评估约旦药剂师对人类微生物组的了解，以及他们的知识对其对抗生素和益生菌的态度及实践的影响。
在查阅文献后设计了一份自填式调查问卷。收集了参与者的人口统计学信息，并询问了评估药剂师对抗生素和益生菌配药的知识、态度及实践的问题。使用社会科学统计软件包V.26对数据进行分析。采用Pearson相关性分析和单因素方差分析来计算知识、态度及实践的显著性。当p < 0.05时认为具有统计学意义。
在333名受访者中，约75%（n = 250）对人类肠道微生物组有较高的一般知识水平。几乎相同比例的参与者分别对肠道细菌在健康中的作用有中级或高级知识水平（n = 164，49.2%）（n = 166，49.8%），而近三分之二的人对肠道细菌在疾病中的作用有中级知识水平（n = 197，59.2%）。超过一半的参与者对抗生素、益生菌和人类微生物组持积极态度（n = 179，53.8%），并且大多数（n = 239，71.8%）对它们的实践处于中级水平。药剂师对人类微生物组的一般知识与他们对抗生素和益生菌的积极态度（= 0.306，p < 0.01）及实践（= 0.331，p < 0.01）之间存在显著正相关。
研究结果凸显了采取干预性教育措施以促进医疗保健专业人员对人类微生物组的了解及其对药剂师在抗生素和益生菌配药方面的态度及实践的潜在益处的重要性。结果还表明迫切需要益生菌临床指南以确保实践的一致性。
