Haider Khawaja Husnain
Department of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia.
World J Stem Cells. 2024 Nov 26;16(11):985-989. doi: 10.4252/wjsc.v16.i11.985.
Stem cell expansion and transplantation in the cytokine-rich proinflammatory milieu in the injured tissue generate immense oxidative stress that interferes with the cells' survival, stemness, and repairability. Stem cell priming has gained popularity to overcome these issues. Given melatonin's oxidative-scavenging properties, Gu have used periodontal ligament stem cells cultured under oxidative stress as an model to study the cytoprotective effects of melatonin. Our letter to the editor delves into melatonin-induced stem cell priming and the underlying molecular mechanism, focusing on the intriguing role of Yes-associated protein signaling in alleviating oxidative stress. We stress the importance of understanding the distinction between and oxidative stress conditions, a crucial aspect of stem cell research that invokes a sense of critical thinking in the readership. The study by Gu presents a novel approach to oxidative stress management, offering exciting possibilities for future research and applications.
在损伤组织中富含细胞因子的促炎环境中进行干细胞扩增和移植会产生巨大的氧化应激，这会干扰细胞的存活、干性和修复能力。干细胞预处理已成为克服这些问题的常用方法。鉴于褪黑素具有氧化清除特性，顾等人使用在氧化应激下培养的牙周膜干细胞作为模型来研究褪黑素的细胞保护作用。我们给编辑的信深入探讨了褪黑素诱导的干细胞预处理及其潜在的分子机制，重点关注Yes相关蛋白信号在减轻氧化应激中的有趣作用。我们强调理解[原文此处缺失部分内容]和氧化应激条件之间差异的重要性，这是干细胞研究的一个关键方面，能引发读者的批判性思维。顾等人的研究提出了一种新的氧化应激管理方法，为未来的研究和应用提供了令人兴奋的可能性。
