Melatonin-based priming of stem cells to alleviate oxidative stress.

Stem cell expansion and transplantation in the cytokine-rich proinflammatory milieu in the injured tissue generate immense oxidative stress that interferes with the cells' survival, stemness, and repairability. Stem cell priming has gained popularity to overcome these issues. Given melatonin's oxidative-scavenging properties, Gu have used periodontal ligament stem cells cultured under oxidative stress as an model to study the cytoprotective effects of melatonin. Our letter to the editor delves into melatonin-induced stem cell priming and the underlying molecular mechanism, focusing on the intriguing role of Yes-associated protein signaling in alleviating oxidative stress. We stress the importance of understanding the distinction between and oxidative stress conditions, a crucial aspect of stem cell research that invokes a sense of critical thinking in the readership. The study by Gu presents a novel approach to oxidative stress management, offering exciting possibilities for future research and applications.