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本文引用的文献

1
Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages.高糖和严重缺氧对不同传代间充质干细胞生物学行为的影响。
World J Stem Cells. 2024 Apr 26;16(4):434-443. doi: 10.4252/wjsc.v16.i4.434.
2
Rheumatoid Synovial Fluid and Acidic Extracellular pH Modulate the Immunomodulatory Activity of Urine-Derived Stem Cells.类风湿性滑液和酸性细胞外 pH 值调节尿源性干细胞的免疫调节活性。
Int J Mol Sci. 2023 Nov 1;24(21):15856. doi: 10.3390/ijms242115856.
3
Epigenetic Reprogramming via Synergistic Hypomethylation and Hypoxia Enhances the Therapeutic Efficacy of Mesenchymal Stem Cell Extracellular Vesicles for Bone Repair.协同去甲基化和低氧诱导的表观遗传重编程增强间充质干细胞外泌体治疗骨修复的疗效。
Int J Mol Sci. 2023 Apr 20;24(8):7564. doi: 10.3390/ijms24087564.
4
Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing.干细胞衍生的外泌体：伤口愈合的新兴治疗机会。
Stem Cell Res Ther. 2023 Apr 26;14(1):107. doi: 10.1186/s13287-023-03345-0.
5
Extracellular matrix protein gelatin provides higher expansion, reduces size heterogeneity, and maintains cell stiffness in a long-term culture of mesenchymal stem cells.细胞外基质蛋白明胶可提供更高的扩增效率，减少细胞大小异质性，并在间充质干细胞的长期培养中维持细胞硬度。
Tissue Cell. 2023 Feb;80:101969. doi: 10.1016/j.tice.2022.101969. Epub 2022 Nov 2.
6
Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review.间充质干细胞在再生医学中的临床应用：叙述性综述。
Stem Cell Res Ther. 2022 Jul 28;13(1):366. doi: 10.1186/s13287-022-03054-0.
7
Senescence State in Mesenchymal Stem Cells at Low Passages: Implications in Clinical Use.低传代间充质干细胞的衰老状态：对临床应用的启示。
Front Cell Dev Biol. 2022 Apr 4;10:858996. doi: 10.3389/fcell.2022.858996. eCollection 2022.
8
Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling.差异氧暴露通过 mTOR 信号调节间充质干细胞代谢和增殖。
Int J Mol Sci. 2022 Mar 29;23(7):3749. doi: 10.3390/ijms23073749.
9
Insight in Hypoxia-Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine.缺氧模拟剂作为再生医学中间充质干细胞预处理潜在工具的见解。
Stem Cells Int. 2022 Mar 26;2022:8775591. doi: 10.1155/2022/8775591. eCollection 2022.
10
Gene Expression Profile of Human Mesenchymal Stromal Cells Exposed to Hypoxic and Pseudohypoxic Preconditioning-An Analysis by RNA Sequencing.缺氧和拟缺氧预处理后人骨髓间充质干细胞的基因表达谱分析——RNA 测序分析。
Int J Mol Sci. 2021 Jul 29;22(15):8160. doi: 10.3390/ijms22158160.

弹性与挑战：评估应激条件对不同传代间间充质干细胞的影响。

Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages.

作者信息

Ding Yue, Lin Fang, Liang Xiao-Ting

机构信息

Department of Organ Transplantation, Naval Medical University, Shanghai 200000, China.

Shanghai Heart Failure Research Center, Shanghai East Hospital, Shanghai 200000, China.

出版信息

World J Stem Cells. 2024 Nov 26;16(11):974-977. doi: 10.4252/wjsc.v16.i11.974.

DOI:10.4252/wjsc.v16.i11.974
PMID:39619876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11606354/
Abstract

This article discussed a study by Almahasneh , which investigated how high glucose and severe hypoxia affected mesenchymal stem cells (MSCs) at different passages. This research provides insights into the resilience of higher-passage MSCs under stress conditions, challenging the common use of lower passage MSCs in clinical settings. While this study offers valuable perspectives on the adaptability of MSCs, it relies mainly on results from a single cell line, limiting broader applicability. It highlights the need for more comprehensive studies to validate these findings and better understand MSC behavior in clinical scenarios.

摘要

本文讨论了阿尔马哈斯内的一项研究，该研究调查了高糖和严重缺氧如何影响不同传代的间充质干细胞（MSC）。这项研究为高传代MSC在应激条件下的恢复力提供了见解，对临床环境中常用低传代MSC提出了挑战。虽然这项研究为MSC的适应性提供了有价值的观点，但它主要依赖于单一细胞系的结果，限制了其更广泛的适用性。它强调需要进行更全面的研究来验证这些发现，并更好地了解MSC在临床场景中的行为。