Gao Ling, Xu Fengyun, Zhen Suli, Cai Yaping
Department of Gynecology and Obstetrics, Jinjiang Hospital Traditional Chinese Medicine, Jinjiang, Fujian, 362200, People's Republic of China.
Int J Womens Health. 2024 Nov 27;16:1981-1991. doi: 10.2147/IJWH.S492712. eCollection 2024.
The Systemic Immune-Inflammation Index (SII) is a novel biomarker that has been implicated in the pathogenesis of various neoplastic and non-neoplastic diseases. This study aimed to evaluate the association between SII and the conventional tumor marker CA125 (Carbohydrate antigen 125) in a population of postmenopausal women.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES), focusing on postmenopausal women with available data on SII and CA125. The SII was calculated using the formula: platelet count × neutrophil count/lymphocyte count. To evaluate the relationship between the SII and cancer antigen 125 (CA125), we conducted multivariate regression analyses. The linear association between these variables was further explored by fitting a smoothed curve to examine nuances in their relationship. Additionally, subgroup analyses were performed based on age, age at menarche and menopause, and hormone replacement therapy status to assess the heterogeneity of the relationship between SII and CA125 between different demographic groups.
A total of 741 postmenopausal women with a mean age of 72.0 (±8.24) years were included in this analysis. The results demonstrated a significant positive correlation between SII and CA125 levels (β = 0.01; 95% CI, 0.00-0.02, p = 0.0128). Subgroup analyses and interaction tests revealed that variables such as age, age at menarche and menopause, and hormone replacement therapy did not significantly modify this association (p > 0.05).
This study demonstrated a positive correlation between SII and C125 in older female patients in the United States.
全身免疫炎症指数（SII）是一种新型生物标志物，与多种肿瘤性和非肿瘤性疾病的发病机制有关。本研究旨在评估绝经后女性人群中SII与传统肿瘤标志物CA125（糖类抗原125）之间的关联。
这项横断面研究利用了美国国家健康与营养检查调查（NHANES）的数据，重点关注有SII和CA125可用数据的绝经后女性。SII使用公式计算：血小板计数×中性粒细胞计数/淋巴细胞计数。为了评估SII与癌抗原125（CA125）之间的关系，我们进行了多变量回归分析。通过拟合平滑曲线进一步探索这些变量之间的线性关联，以检查它们关系中的细微差别。此外，根据年龄、初潮和绝经年龄以及激素替代疗法状态进行亚组分析，以评估不同人口统计学组之间SII与CA125关系的异质性。
本分析共纳入741名平均年龄为72.0（±8.24）岁的绝经后女性。结果显示SII与CA125水平之间存在显著正相关（β = 0.01；95% CI，0.00 - 0.02，p = 0.0128）。亚组分析和交互检验显示，年龄、初潮和绝经年龄以及激素替代疗法等变量并未显著改变这种关联（p > 0.05）。
本研究表明，在美国老年女性患者中，SII与C125之间存在正相关。
