Sharma Pankaj, Mishra Vedante, Murab Sumit
School of Biosciences & Bioengineering, Indian Institute of Technology Mandi, Kamand HP-175075, India.
Indian Knowledge System and Mental Health Applications Centre, Indian Institute of Technology Mandi, Kamand HP-175075, India.
ACS Biomater Sci Eng. 2025 Jan 13;11(1):67-94. doi: 10.1021/acsbiomaterials.4c01178. Epub 2024 Dec 2.
Tooth loss is a prevalent problem faced by individuals of all ages across the globe. Various biomaterials, such as metals, bioceramics, polymers, composites of ceramics and polymers, etc., have been used for the manufacturing of dental implants. The success of a dental implant primarily depends on its osseointegration rate. The current surface modification techniques fail to imbibe the basics of tooth development, which can impart better mineralization and osseointegration. This can be improved by developing an understanding of the developmental pathways of dental tissue. Stimulating the correct signaling pathways through inductive material systems can bring about a paradigm shift in dental implant materials. The current review focuses on the developmental pathway and mineralization process that happen during tooth formation and how surface modifications can help in biomimetic mineralization, thereby enhancing osseointegration. We further describe the effect of dental implant surface modifications on mineralization, osteoinduction, and osseointegration; both and . The review will help us to understand the natural process of teeth development and mineralization and how the surface properties of dental implants can be further improved to mimic teeth development, in turn increasing osseointegration.
牙齿缺失是全球各年龄段人群面临的一个普遍问题。各种生物材料，如金属、生物陶瓷、聚合物、陶瓷与聚合物的复合材料等，已被用于制造牙科植入物。牙科植入物的成功主要取决于其骨结合率。当前的表面改性技术未能吸收牙齿发育的基本原理，而这些原理可以实现更好的矿化和骨结合。通过深入了解牙组织的发育途径可以改善这一状况。通过诱导材料系统激活正确的信号通路能够给牙科植入材料带来范式转变。本综述聚焦于牙齿形成过程中发生的发育途径和矿化过程，以及表面改性如何有助于仿生矿化，从而增强骨结合。我们还描述了牙科植入物表面改性对矿化、骨诱导和骨结合的影响；包括体内和体外的情况。这篇综述将帮助我们理解牙齿发育和矿化的自然过程，以及如何进一步改善牙科植入物的表面特性以模拟牙齿发育，进而提高骨结合。
