Wang Qihong, Jia Wen, Liu Jiao, Zhao Qian, Yang Zhuo
Department of Digestive Endoscopy, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, China.
Eur J Gastroenterol Hepatol. 2025 Apr 1;37(4):466-476. doi: 10.1097/MEG.0000000000002899. Epub 2024 Dec 3.
Liver cancer is a major global health burden, with alcohol use being a well-established risk factor. This study aims to analyze the global, regional, and national incidence, prevalence, mortality, and disability-adjusted life years (DALYs) attributable to liver cancer due to alcohol use from 1990 to 2021.
Data on liver cancer due to alcohol use were collected from the 2021 Global Burden of Disease (GBD) study. The changing trend of liver cancer among alcohol users was described using the linear regression model. In addition, we employed a hierarchical cluster analysis to study the evolving patterns across diverse GBD regions and conducted a frontier analysis to explore the nexus between the burden and sociodemographic progress.
In 2021, alcohol-related liver cancer globally accounted for 99 544 incidence cases, 132 033 prevalence cases, 92 228 death cases, and 2 316 027 DALYs cases. Males and middle-aged adults emerged as high-risk populations, while regions with a higher sociodemographic index (SDI) were identified as high-risk areas. From 1990 to 2021, both the number of cases and age-standardized rates (ASRs) increased. Our frontier analysis revealed unattained health gains between 1990 and 2021, highlighting disparities in disease burden among countries with varying SDI levels. This analysis further demonstrated an inverse correlation between SDI and alcohol-related liver cancer ASRs, with the ASRs stabilizing once the SDI exceeded 0.40.
Alcohol use is a significant contributor to the global burden of liver cancer. Comprehensive policies and interventions targeting alcohol use are needed to reduce the burden of alcohol-related liver cancer.
肝癌是一项重大的全球健康负担，饮酒是一个公认的风险因素。本研究旨在分析1990年至2021年因饮酒导致的肝癌在全球、区域和国家层面的发病率、患病率、死亡率以及伤残调整生命年（DALYs）。
从2021年全球疾病负担（GBD）研究中收集因饮酒导致的肝癌数据。使用线性回归模型描述饮酒者中肝癌的变化趋势。此外，我们采用层次聚类分析研究不同GBD区域的演变模式，并进行前沿分析以探索负担与社会人口学进展之间的关系。
2021年，全球与酒精相关的肝癌发病病例为99544例，患病病例为132033例，死亡病例为92228例，伤残调整生命年病例为2316027例。男性和中年成年人是高危人群，而社会人口学指数（SDI）较高的地区被确定为高危地区。从1990年到2021年，病例数和年龄标准化率（ASRs）均有所增加。我们的前沿分析揭示了1990年至2021年期间未实现的健康收益，凸显了不同SDI水平国家之间疾病负担的差异。该分析进一步表明SDI与酒精相关肝癌ASRs之间呈负相关，当SDI超过0.40时，ASRs趋于稳定。
饮酒是全球肝癌负担的重要促成因素。需要制定针对饮酒的综合政策和干预措施，以减轻酒精相关肝癌的负担。
