Teuber J, Brehm H, Stumpf J
Immun Infekt. 1979 Dec;7(6):213-21.
Trichinella spiralis was detected in 1835 by Paget, an English student. Since the introduction of the meat investigation law for trichinosis in 1937 the infection with this parasites became a rare condition. The last endemies in Germany occurred in 1967 and 1977. They restimulated the discussion regarding the efficiency and sensitivity of the routinely used methods for the detection of Tr. spiralis. 69 patients, suffering from infection with Tr. spiralis were investigated using a modified IFT. This method was compared with other serological techniques for the determination of Tr. spiralis and was found very sensitive and specific. Further immunological investigations showed an increased lymphocyte stimulation with Trich. antigen in most patients suffering from trichinellosis. When added autologous serum however the proliferation of lymphocytes was inhibited. The reason for this phenomenon might be a factor with immunosuppressive property produced by the adult worms.
1835年，英国学生佩吉特发现了旋毛虫。自1937年出台旋毛虫病肉类检查法以来，这种寄生虫感染已变得罕见。德国上一次地方性流行发生在1967年和1977年。它们重新引发了关于常规用于检测旋毛虫的方法的效率和敏感性的讨论。对69名感染旋毛虫的患者使用改良的间接荧光抗体试验（IFT）进行了调查。将该方法与其他用于检测旋毛虫的血清学技术进行比较，发现其非常敏感且特异。进一步的免疫学研究表明，大多数旋毛虫病患者对旋毛虫抗原的淋巴细胞刺激增加。然而，加入自体血清后，淋巴细胞的增殖受到抑制。这种现象的原因可能是成虫产生的一种具有免疫抑制特性的因子。
