Ausserwinkler M, Altrichter H, Türk H, Schmidt P
Wien Klin Wochenschr. 1986 Feb 7;98(3):78-82.
3 cardiovascular reflexes were tested in 25 patients on regular haemodialysis: measurement of the beat-to-beat variation in heart rate in the supine position and during deep breathing, measurement of heart rate response to change in posture (30:15 ratio). 8 patients (32%) had abnormal results in at least two of the tests, 3 patients (12%) had abnormal results in all 3 tests. Beat-to-beat variation was found to be the most sensitive test, the heart rate difference during deep breathing showing a direct correlation to the nerve conduction velocity of the peroneal nerve. Hence, a common cause can be postulated in the pathogenesis of the autonomic lesions and the sensorimotor polyneuropathy in the patients under investigation. Furthermore, the group with the most severe radiological calcification due to Mönckeberg's medial sclerosis had a significantly lower mean heart rate difference during deep breathing than the group with no radiological calcification. A similar correlation between autonomic neuropathy and Mönckeberg's medial sclerosis has recently been described in diabetic patients.
对25例定期进行血液透析的患者进行了3种心血管反射测试：测量仰卧位和深呼吸时心率的逐搏变化，测量心率对姿势改变的反应（30:15比值）。8例患者（32%）至少两项测试结果异常，3例患者（12%）所有3项测试结果均异常。发现逐搏变化是最敏感的测试，深呼吸时的心率差异与腓总神经的神经传导速度呈直接相关。因此，可以推测在所研究患者的自主神经病变和感觉运动性多神经病的发病机制中有一个共同原因。此外，因蒙克贝格（Mönckeberg）中膜硬化导致最严重放射学钙化的组，深呼吸时的平均心率差异显著低于无放射学钙化的组。最近在糖尿病患者中也描述了自主神经病变与蒙克贝格中膜硬化之间的类似相关性。
