Katamanin Olivia M, Tan Isabella J, Barry Jillian, Jafferany Mohammad
Chicago Medical School, Rosalind Franklin University, North Chicago, IL, 60064, USA.
Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Am J Clin Dermatol. 2025 Jan;26(1):35-43. doi: 10.1007/s40257-024-00905-9. Epub 2024 Dec 2.
The growing field of psychodermatology examines the interplay between dermatological and psychiatric comorbidities. While current literature recognizes that cutaneous and psychiatric conditions often coexist within patients, the relationship between dysregulated inflammation and depression in patients with inflammatory skin conditions has not been thoroughly explored. This review seeks to describe the connection between cutaneous disease and depression via shared inflammatory cytokine pathways. A review of current literature was conducted, and studies addressing the co-occurrence of depression and inflammatory skin diseases were included. This review focuses on depression in patients with psoriasis, atopic dermatitis, and hidradenitis suppurativa. Studies that focused on the prevalence of depression in these populations, shared inflammatory pathways, and co-management of cutaneous and psychiatric disorders were chosen. The literature revealed a high prevalence of depression in individuals with inflammatory skin conditions compared with those without cutaneous disease. Recent studies described how proinflammatory cytokines in inflammatory skin diseases can elicit inflammation in the brain, leading to depressive symptoms. Certain subsets of cytokines that mediate inflammatory pathways were associated with both cutaneous inflammation and depression, highlighting shared pathology. Antiinflammatory medications targeting shared cytokines found reductions in both cutaneous and depressive symptoms. Practitioners have emphasized interdisciplinary approaches to treating both conditions, including psychotherapy and pharmacological methods. There is a clear association between inflammatory cutaneous diseases and depression. Co-management of these conditions, including interdisciplinary methods, is essential for patients' well-being. Future research addressing similar links between other cutaneous and psychiatric conditions could yield new treatment opportunities as well.
心理皮肤病学这一不断发展的领域研究皮肤病与精神疾病合并症之间的相互作用。虽然当前文献认识到皮肤疾病和精神疾病在患者中常常并存，但炎症性皮肤病患者中炎症调节异常与抑郁症之间的关系尚未得到充分探讨。本综述旨在通过共享的炎症细胞因子途径描述皮肤疾病与抑郁症之间的联系。我们对当前文献进行了检索，并纳入了探讨抑郁症与炎症性皮肤病共现情况的研究。本综述聚焦于银屑病、特应性皮炎和化脓性汗腺炎患者的抑郁症。我们选取了关注这些人群中抑郁症患病率、共享炎症途径以及皮肤和精神疾病联合管理的研究。文献显示，与无皮肤疾病的个体相比，炎症性皮肤病患者中抑郁症的患病率较高。近期研究描述了炎症性皮肤病中的促炎细胞因子如何引发脑部炎症，导致抑郁症状。介导炎症途径的某些细胞因子亚群与皮肤炎症和抑郁症均相关，凸显了共同的病理机制。针对共享细胞因子的抗炎药物可使皮肤症状和抑郁症状均减轻。从业者强调采用跨学科方法来治疗这两种疾病，包括心理治疗和药物治疗方法。炎症性皮肤病与抑郁症之间存在明显关联。对这些疾病进行联合管理，包括采用跨学科方法，对患者的健康至关重要。未来针对其他皮肤疾病与精神疾病之间类似联系的研究也可能带来新的治疗机会。
