Wang Liucan, Chen Guoqing, Yang Yang, Xu Chao, Zhu Li, Yang Hua, Yu Min
Department of General Surgery, Chongqing General Hospital, Chongqing, People's Republic of China.
J Inflamm Res. 2024 Nov 27;17:9889-9904. doi: 10.2147/JIR.S487942. eCollection 2024.
Oxidative stress, characterized by excessive production of reactive oxygen species (ROS), is a critical factor in the progression of inflammatory bowel disease (IBD) and presents a potential therapeutic target. Anti-oxidant therapy, aimed at mitigating excessive ROS, is emerging as a cornerstone in IBD treatment. Nanomaterials with robust anti-oxidant properties offer promise by inhibiting inflammation through ROS scavenging, enhancing IBD therapeutic efficacy. Recent focus in ROS scavenging has centered on metal oxide nanoenzymes and polyphenol-based nanomaterials. The primary challenges are the catalytic efficiency of nanoenzymes and the functional integration of these nanomaterials with therapeutic agents. Polyphenols, natural plant extracts, have garnered significant interest due to their potent anti-oxidant properties and unique catechol groups that interact with biomolecules such as proteins and nucleic acids. The strong metal ion chelating ability of catechols enriches the structure and functionality of nanomaterials, improving the physicochemical properties of nanocarriers and enabling innovative designs of multifunctional drug delivery systems (DDSs). Research on polyphenol-based DDSs has expanded to include agents like epigallocatechin gallate, curcumin, resveratrol, tannic acid, and polydopamine. These nanocarriers and anti-oxidants, which incorporate polyphenols, have demonstrated potential anti-oxidant properties in novel DDSs as therapeutic agents to reduce inflammation and as essential components of drug carriers. This review focuses on the design and application of natural polyphenol-based anti-oxidant nanomaterials for IBD treatment, offering a comprehensive discussion on the use of polyphenols in DDSs and the potential challenges posed by their diverse roles in innovative drug delivery strategies, including their impact on the physical and chemical properties of DDSs.
氧化应激以活性氧（ROS）的过量产生为特征，是炎症性肠病（IBD）进展中的关键因素，并呈现出一个潜在的治疗靶点。旨在减轻过量ROS的抗氧化疗法正成为IBD治疗的基石。具有强大抗氧化性能的纳米材料通过清除ROS抑制炎症，有望提高IBD治疗效果。目前ROS清除方面的研究重点集中在金属氧化物纳米酶和基于多酚的纳米材料上。主要挑战在于纳米酶的催化效率以及这些纳米材料与治疗剂的功能整合。多酚是天然植物提取物，因其强大的抗氧化性能和与蛋白质、核酸等生物分子相互作用的独特儿茶酚基团而备受关注。儿茶酚强大的金属离子螯合能力丰富了纳米材料的结构和功能，改善了纳米载体的物理化学性质，并实现了多功能药物递送系统（DDS）的创新设计。基于多酚的DDS研究已扩展到包括表没食子儿茶素没食子酸酯、姜黄素、白藜芦醇、单宁酸和聚多巴胺等药物。这些包含多酚的纳米载体和抗氧化剂在新型DDS中已展现出潜在的抗氧化性能，可作为治疗剂减轻炎症，也可作为药物载体的重要组成部分。本综述聚焦于基于天然多酚的抗氧化纳米材料在IBD治疗中的设计与应用，全面讨论了多酚在DDS中的应用以及它们在创新药物递送策略中因其多种作用所带来的潜在挑战，包括它们对DDS物理化学性质的影响。
