State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China; Macau Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Chemistry Department, American University in Cairo AUC, Cairo, Egypt.
Adv Drug Deliv Rev. 2021 Sep;176:113870. doi: 10.1016/j.addr.2021.113870. Epub 2021 Jul 16.
As naturally occurring bioactive products, several lines of evidence have shown the potential of polyphenols in the medical intervention of various diseases, including tumors, inflammatory diseases, and cardiovascular diseases. Notably, owing to the particular molecular structure, polyphenols can combine with proteins, metal ions, polymers, and nucleic acids providing better strategies for polyphenol-delivery strategies. This contributes to the inherent advantages of polyphenols as important functional components for other drug delivery strategies, e.g., protecting nanodrugs from oxidation as a protective layer, improving the physicochemical properties of carbohydrate polymer carriers, or being used to synthesize innovative functional delivery vehicles. Polyphenols have emerged as a multifaceted player in novel drug delivery systems, both as therapeutic agents delivered to intervene in disease progression and as essential components of drug carriers. Although an increasing number of studies have focused on polyphenol-based nanodrug delivery including epigallocatechin-3-gallate, curcumin, resveratrol, tannic acid, and polyphenol-related innovative preparations, these molecules are not without inherent shortcomings. The active biochemical characteristics of polyphenols constitute a prerequisite to their high-frequency use in drug delivery systems and likewise to provoke new challenges for the design and development of novel polyphenol drug delivery systems of improved efficacies. In this review, we focus on both the targeted delivery of polyphenols and the application of polyphenols as components of drug delivery carriers, and comprehensively elaborate on the application of polyphenols in new types of drug delivery systems. According to the different roles played by polyphenols in innovative drug delivery strategies, potential limitations and risks are discussed in detail including the influences on the physical and chemical properties of nanodrug delivery systems, and their influence on normal physiological functions inside the organism.
作为天然存在的生物活性产物，有几条证据表明多酚在各种疾病（包括肿瘤、炎症性疾病和心血管疾病）的医学干预中的潜力。值得注意的是，由于特殊的分子结构，多酚可以与蛋白质、金属离子、聚合物和核酸结合，为多酚递药策略提供了更好的策略。这有助于多酚作为其他药物递药策略的重要功能成分的固有优势，例如，作为保护层保护纳米药物免受氧化，改善碳水化合物聚合物载体的物理化学性质，或用于合成创新的功能递药载体。多酚作为新型药物递药系统中的多面手出现，既是递送到干预疾病进展的治疗剂，也是药物载体的重要组成部分。尽管越来越多的研究集中在基于多酚的纳米药物递药上，包括表没食子儿茶素没食子酸酯、姜黄素、白藜芦醇、单宁酸和多酚相关的创新制剂，但这些分子并非没有内在的缺点。多酚的主动生化特性是其在药物递药系统中高频使用的前提，同样也为设计和开发疗效提高的新型多酚药物递药系统带来了新的挑战。在这篇综述中，我们重点关注多酚的靶向递药和多酚作为药物递药载体成分的应用，并全面阐述了多酚在新型药物递药系统中的应用。根据多酚在创新药物递药策略中扮演的不同角色，详细讨论了潜在的局限性和风险，包括对纳米药物递药系统物理化学性质的影响，以及对机体内部正常生理功能的影响。
