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鼻黏液细胞因子与合并哮喘的慢性鼻-鼻窦炎患者的肺功能测量值相关。

Nasal Mucus Cytokines Are Correlated with Spirometry Measures in CRS Patients with Comorbid Asthma.

作者信息

Lubner Rory J, Dorismond Christina, Krysinski Mason, Li Ping, Chandra Rakesh K, Turner Justin H, Newcomb Dawn C, Cahill Katherine N, Chowdhury Naweed I

机构信息

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Department of Otolaryngology-Head and Neck Surgery, University of Alabama-Birmingham, Birmingham, Alabama, USA.

出版信息

Int Forum Allergy Rhinol. 2025 Mar;15(3):350-353. doi: 10.1002/alr.23492. Epub 2024 Dec 3.

DOI:10.1002/alr.23492
PMID:39624918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11872784/
Abstract

CRS patients with asthma show differential nasal mucus cytokine signatures based on endotype. IL-7 concentration is positively associated with higher %FEV1 and %FVC in CRS patients with asthma.

摘要

患有哮喘的慢性鼻-鼻窦炎（CRS）患者根据内型表现出不同的鼻腔黏液细胞因子特征。在患有哮喘的CRS患者中，白细胞介素-7浓度与较高的第一秒用力呼气容积（%FEV1）和用力肺活量（%FVC）呈正相关。

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Nasal Mucus Cytokines Are Correlated with Spirometry Measures in CRS Patients with Comorbid Asthma.鼻黏液细胞因子与合并哮喘的慢性鼻-鼻窦炎患者的肺功能测量值相关。
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Am J Rhinol Allergy. 2009 Nov-Dec;23(6):e10-3. doi: 10.2500/ajra.2009.23.3389.
3
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本文引用的文献

1
GM-CSF instigates a dendritic cell-T-cell inflammatory circuit that drives chronic asthma development.GM-CSF 引发树突状细胞-T 细胞炎症回路，驱动慢性哮喘发展。
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International consensus statement on allergy and rhinology: rhinosinusitis 2021.《2021年变应性鼻炎和鼻科学国际共识声明：鼻窦炎》
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3
Bidirectional association between asthma and chronic rhinosinusitis: Two longitudinal follow-up studies using a national sample cohort.哮喘与慢性鼻-鼻窦炎的双向关联：基于全国样本队列的两项纵向随访研究。
Sci Rep. 2020 Jun 12;10(1):9589. doi: 10.1038/s41598-020-66479-8.
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Targeting the interleukin-7 receptor alpha by an anti-CD127 monoclonal antibody improves allergic airway inflammation in mice.靶向白细胞介素-7 受体 α 的抗 CD127 单克隆抗体可改善小鼠过敏性气道炎症。
Clin Exp Allergy. 2020 Jul;50(7):824-834. doi: 10.1111/cea.13665. Epub 2020 Jun 16.
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The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma.共同γ链细胞因子白细胞介素-7 在真菌性哮喘期间促进免疫发病机制。
Mucosal Immunol. 2018 Sep;11(5):1352-1362. doi: 10.1038/s41385-018-0028-1. Epub 2018 Jun 15.
6
Mucus T helper 2 biomarkers predict chronic rhinosinusitis disease severity and prior surgical intervention.黏液 T 辅助 2 生物标志物可预测慢性鼻-鼻窦炎疾病严重程度和既往手术干预情况。
Int Forum Allergy Rhinol. 2018 Oct;8(10):1175-1183. doi: 10.1002/alr.22160. Epub 2018 Jun 8.
7
Elevated Serum Interleukin-8 Level as a Preferable Biomarker for Identifying Uncontrolled Asthma and Glucocorticosteroid Responsiveness.血清白细胞介素-8水平升高作为识别未控制哮喘和糖皮质激素反应性的优选生物标志物
Tanaffos. 2017 Jun;16(4):260-269.
8
Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited.哮喘、变应性鼻炎和慢性鼻-鼻窦炎的上下气道重塑机制：重新审视一个气道概念。
Allergy. 2018 May;73(5):993-1002. doi: 10.1111/all.13373. Epub 2017 Dec 22.
9
Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease.IFN-γ 在阿司匹林加重性呼吸系统疾病患者中发挥重要作用。
J Allergy Clin Immunol. 2013 Oct;132(4):856-65.e1-3. doi: 10.1016/j.jaci.2013.05.008. Epub 2013 Jun 24.