吡格列酮治疗的沃纳综合征患者皮肤溃疡发生率较低：来自日本沃纳综合征登记处的研究结果。

Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry.

作者信息

Aono Kazuto, Koshizaka Masaya, Shoji Mayumi, Kaneko Hiyori, Maeda Yukari, Kato Hisaya, Maezawa Yoshiro, Miyabayashi Makoto, Ishikawa Mai, Sekiguchi Akiko, Motegi Sei-Ichiro, Tsukamoto Shinji, Taniguchi Akira, Shoda Yukiko, Yoshimura Toru, Kawashima Junji, Yoshinaga Kayo, Nakagami Hironori, Takami Yoichi, Sugimoto Ken, Hashimoto Kunihiko, Okubo Naoki, Yoshida Takashi, Ohara Masato, Kogure Asako, Suzuki Daisuke, Kuzuya Masafumi, Watanabe Kazuhisa, Takemoto Minoru, Oshima Junko, Yokote Koutaro

机构信息

Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.

Center for Preventive Medical Sciences, Chiba University, Chiba, Japan.

出版信息

Aging (Albany NY). 2024 Dec 2;16(22):13526-13533. doi: 10.18632/aging.206161.

DOI:10.18632/aging.206161

PMID:39625398

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11723649/

Abstract

BACKGROUND AND AIM

Werner syndrome (WS) is an autosomal recessive, adult-onset, progeroid syndrome caused by mutations. As refractory skin ulcers significantly affect the quality of life of patients with WS, this study identified ulcer risk factors and assessed prevention methods.

METHODS

We analyzed the data of 51 patients with WS enrolled in the Japanese Werner Syndrome Registry between 2016 and 2022. A cross-sectional analysis was performed to determine the association with skin ulcers at baseline. Statistical analyses were conducted, including Welch's and Pearson's chi-square tests. Age was adjusted using a logistic regression model.

RESULTS

The mean patient age was 48.8±7.6 years, and 66.7% of patients presented with skin ulcers. Univariate analysis showed that patients with skin ulcers were older than those without ulcers. Systolic blood pressure (SBP) was higher in patients with skin ulcers. Patients without skin ulcers received metformin and pioglitazone treatment significantly more often than those with ulcers. Logistic regression analysis adjusted for age showed that higher SBP remained a significant risk factor for skin ulcers. Patients administered pioglitazone had lower ulcer morbidity.

CONCLUSIONS

Age and SBP are risk factors for skin ulcers in patients with WS. Moreover, pioglitazone treatment may prevent skin ulcers.

摘要

背景与目的

沃纳综合征（WS）是一种由突变引起的常染色体隐性、成人发病的早老综合征。由于难治性皮肤溃疡严重影响WS患者的生活质量，本研究确定了溃疡危险因素并评估了预防方法。

方法

我们分析了2016年至2022年期间纳入日本沃纳综合征登记处的51例WS患者的数据。进行横断面分析以确定基线时与皮肤溃疡的关联。进行了统计分析，包括韦尔奇检验和皮尔逊卡方检验。使用逻辑回归模型对年龄进行调整。

结果

患者的平均年龄为48.8±7.6岁，66.7%的患者出现皮肤溃疡。单因素分析显示，有皮肤溃疡的患者比没有溃疡的患者年龄更大。有皮肤溃疡的患者收缩压（SBP）更高。没有皮肤溃疡的患者接受二甲双胍和吡格列酮治疗的频率明显高于有溃疡的患者。经年龄调整的逻辑回归分析显示，较高的SBP仍然是皮肤溃疡的一个重要危险因素。服用吡格列酮的患者溃疡发病率较低。