Ettadili Hamza, Vural Caner
Faculty of Science, Department of Biology, Molecular Biology Section, Pamukkale University, 20160, Denizli, Türkiye.
Appl Biochem Biotechnol. 2025 Mar;197(3):1923-1945. doi: 10.1007/s12010-024-05120-0. Epub 2024 Dec 3.
Nanozymes are a class of nanomaterials that are capable of mimicking the activities of natural enzymes. They are currently receiving considerable attention due to their advantageous properties. The objective of this study is to provide a comprehensive analysis of the advancements and trends in nanozymes for microbial theranostics research over the past decade through a detailed bibliometric approach. For this purpose, an effective search query was formulated, and relevant publications from 2013 to 2023 were collected from the Web of Science Core Collection database. Subsequently, the following softwares were employed for analysis: VOSviewer, the Bibliometrix R package, and GraphPad Prism 8.0.2. The findings revealed a statistically significant positive correlation (r = 0.993; p < 0.0001) between publications and citations, in addition to an important growth rate of scientific output of approximately 28.90%. China, India, and the USA were the most productive countries, whereas progress in low- and middle-income countries remained constrained. The Chinese Academy of Sciences was the most productive institution, and remarkably almost the top 10 productive authors were from China. Regarding keywords analysis, current research hotspots are primarily concentrated on the application of nanozymes in anti-biofilm-related research, antibacterial activity and therapy, the development of biosensors for microbial detection and control, and the advancement of wound disinfection and therapy.
纳米酶是一类能够模拟天然酶活性的纳米材料。由于其具有的优势特性，目前它们正受到广泛关注。本研究的目的是通过详细的文献计量方法，全面分析过去十年纳米酶在微生物诊疗研究方面的进展和趋势。为此，制定了一个有效的检索式，并从科学网核心合集数据库中收集了2013年至2023年的相关出版物。随后，使用了以下软件进行分析：VOSviewer、Bibliometrix R软件包和GraphPad Prism 8.0.2。研究结果显示，出版物与被引频次之间存在统计学上显著的正相关（r = 0.993；p < 0.0001），此外科学产出的重要增长率约为28.90%。中国、印度和美国是产出最多的国家，而低收入和中等收入国家的进展仍然受限。中国科学院是产出最多的机构，而且几乎排名前十的高产作者都来自中国。关于关键词分析，当前的研究热点主要集中在纳米酶在抗生物膜相关研究、抗菌活性与治疗、用于微生物检测与控制的生物传感器开发以及伤口消毒与治疗进展方面的应用。
