Recoverable peroxidase-like FeO@MoS-Ag nanozyme with enhanced antibacterial ability.

Antibacterial agents with enzyme-like properties and bacteria-binding ability have provided an alternative method to efficiently disinfect drug-resistance microorganism. Herein, a FeO@MoS-Ag nanozyme with defect-rich rough surface was constructed by a simple hydrothermal method and photodeposition of Ag nanoparticles. The nanozyme exhibited good antibacterial performance against (69.4%) by the generated ROS and released Ag, while the nanozyme could further achieve an excellent synergistic disinfection (100%) by combining with the near-infrared photothermal property of FeO@MoS-Ag. The antibacterial mechanism study showed that the antibacterial process was determined by the collaborative work of peroxidase-like activity, photothermal effect and leakage of Ag. The defect-rich rough surface of MoS layers facilitated the capture of bacteria, which enhanced the accurate and rapid attack of •OH and Ag to the membrane of with the assistance of local hyperthermia. This method showed broad-spectrum antibacterial performance against Gram-negative bacteria, Gram-positive bacteria, drug-resistant bacteria and fungal bacteria. Meanwhile, the magnetism of FeO was used to recycle the nanozyme. This work showed great potential of engineered nanozymes for efficient disinfection treatment.