Schmidt S H, Hellström S, Carlsöö B
Acta Otolaryngol. 1986 Jan-Feb;101(1-2):88-95. doi: 10.3109/00016488609108611.
The tympanic membrane of the rat was studied ultrastructurally after application of a local anaesthetic--lidocaine spray. Already after 10 min, degenerative changes--or even necrosis--were observed on both epithelial surfaces of the eardrum. Later on, a marked hyperplasia of the epidermal layer was most characteristic, as was a proliferation of the fibroblasts of the subepithelial connective tissue. After 3 weeks the eardrum had not regained its normal appearance. No perforations were encountered and only minute substructural changes could be detected within the fibrous layer.
在对大鼠鼓膜局部应用局部麻醉剂——利多卡因喷雾剂后，对其进行了超微结构研究。仅在10分钟后，就观察到鼓膜的两个上皮表面出现退行性变化——甚至坏死。随后，表皮层明显增生最为显著，上皮下结缔组织的成纤维细胞也出现增殖。3周后，鼓膜仍未恢复其正常外观。未发现穿孔，仅在纤维层内检测到微小的亚结构变化。
