Schmidt S H, Hellström S
Department of Otorhinolaryngology & Head and Neck Surgery, University of Umeå, Sweden.
Eur Arch Otorhinolaryngol. 1993;249(8):470-2. doi: 10.1007/BF00168857.
In the present study, local anesthetics were applied to the tympanic membrane (TM) of rats following experimentally evoked purulent otitis media (POM). The structure of the TM was evaluated 24 h, 2 weeks and 3 months after application of phenol to a discrete are of the right TM. The left ear was used as a control. POM induced swelling of all tissue layers of the pears tensa. The tissues were invaded by inflammatory cells and disintegrated. The fibrous layer also dissolved, leaving spontaneous perforations. However, phenol on inflamed TMs did not further alter the TM structure. These findings infer that the injurious effect of topical anesthesia on the intact TM is more or less negligible when applied to diseased TMs.
在本研究中，在实验诱发大鼠化脓性中耳炎（POM）后，将局部麻醉剂应用于大鼠的鼓膜（TM）。在将苯酚应用于右TM的离散区域后24小时、2周和3个月，评估TM的结构。左耳用作对照。POM导致紧张部鼓膜的所有组织层肿胀。组织被炎性细胞侵袭并解体。纤维层也溶解，留下自发性穿孔。然而，炎性TM上的苯酚并没有进一步改变TM的结构。这些发现表明，当应用于患病的TM时，局部麻醉对完整TM的损伤作用或多或少可以忽略不计。
