Wang Cheng, Lee Heekyung, Rao Geeta, Knierim James J
Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
CAS Key Laboratory of Brain Connectome and Manipulation, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Nat Commun. 2024 Dec 3;15(1):10533. doi: 10.1038/s41467-024-54932-5.
Episodic memory involves the processing of spatial and temporal aspects of personal experiences. The lateral entorhinal cortex (LEC) plays an essential role in subserving memory. However, the mechanisms by which LEC integrates spatial and temporal information remain elusive. Here, we recorded LEC neurons while male rats performed one-dimensional tasks. Many LEC cells displayed spatial firing fields and demonstrated selectivity for traveling directions. Furthermore, some LEC neurons changed the firing rates of their spatial rate maps during a session (rate remapping). Importantly, this temporal modulation was consistent across sessions, even when the spatial environment was altered. Notably, the strength of temporal modulation was greater in LEC compared to other brain regions, such as the medial entorhinal cortex, CA1, and CA3. Thus, we demonstrate spatial rate mapping in LEC neurons, which may serve as a coding mechanism for temporal context, and allow for flexible multiplexing of spatial and temporal information.
情景记忆涉及对个人经历的空间和时间方面的处理。外侧内嗅皮层（LEC）在支持记忆方面起着至关重要的作用。然而，LEC整合空间和时间信息的机制仍然难以捉摸。在这里，我们在雄性大鼠执行一维任务时记录了LEC神经元。许多LEC细胞显示出空间放电场，并表现出对行进方向的选择性。此外，一些LEC神经元在一个实验过程中改变了其空间速率图的放电率（速率重映射）。重要的是，即使空间环境发生改变，这种时间调制在不同实验过程中也是一致的。值得注意的是，与其他脑区（如内侧内嗅皮层、CA1和CA3）相比，LEC中的时间调制强度更大。因此，我们证明了LEC神经元中的空间速率映射，这可能作为时间背景的编码机制，并允许空间和时间信息的灵活复用。
