Li Chenyang, Wang Jinjun, Wang Lingling, Guo Jing, Li Jinjie, Li Xinxin, Li Lifeng, Zhang Junxi, Suo Xiangying
College of Geography and Environmental Science, Henan University, Kaifeng, 475004, Henan, China.
Henan Urban Plan and Design Institute Co., Ltd, Zhengzhou, 450044, China.
Sci Rep. 2024 Dec 3;14(1):30075. doi: 10.1038/s41598-024-81255-8.
The impact of volatile organic compounds (VOCs) on type 2 diabetes (T2D) among older adults is unknown. The multiple linear regression model and the multiple binary logistic regression were used to evaluate the relationships between mVOCs and glucose homeostasis/T2D, respectively. Among the 19 mVOCs, the higher levels of urinary N-acetyl-S-(2-hydroxypropyl)-L-cysteine (2HPMA, compound CID:44146439) and N-acetyl-S-(2-hydroxypropyl)-L-cysteine (HPMMA, compound CID:107774684) were significantly associated with higher odds of T2D (OR = 1.16, 95% confidence interval [CI]:1.01-1.34 for 2HPMA; and OR = 1.27, 95% CI:1.04-1.54 for HPMMA). In addition, higher concentrations of multiple mVOCs in urine were significantly correlated with glucose homeostasis biomarkers, including 2HPMA and 2-thioxothiazolidine-4-carboxylic acid (TTCA, compound CID:3034757) with fasting glucose, HPMMA and mandelic acid (MA, compound CID:1292) with HbA1c, phenylglyoxylic acid (PGA, compound CID:11915) with serum insulin, HbA1c and HOMA-IR. Our findings suggested that exposure to VOCs were associated with increased odds of T2D in older adults, which might be mediated by impaired glucose homeostasis. Mitigating VOCs should be a necessary component of public health strategies aimed at reducing the burden of type 2 diabetes.
挥发性有机化合物（VOCs）对老年人2型糖尿病（T2D）的影响尚不清楚。分别使用多元线性回归模型和多元二元逻辑回归来评估多种挥发性有机化合物（mVOCs）与葡萄糖稳态/T2D之间的关系。在19种mVOCs中，尿中N-乙酰-S-（2-羟丙基）-L-半胱氨酸（2HPMA，化合物登录号：44146439）和N-乙酰-S-（2-羟丙基）-L-半胱氨酸（HPMMA，化合物登录号：107774684）水平较高与T2D的较高患病几率显著相关（2HPMA的比值比[OR]=1.16，95%置信区间[CI]：1.01-1.34；HPMMA的OR=1.27，95%CI：1.04-1.54）。此外，尿中多种mVOCs的较高浓度与葡萄糖稳态生物标志物显著相关，包括2HPMA和2-硫代噻唑烷-4-羧酸（TTCA，化合物登录号：3034757）与空腹血糖，HPMMA和扁桃酸（MA，化合物登录号：1292）与糖化血红蛋白（HbA1c），苯甲酰甲酸（PGA，化合物登录号：11915）与血清胰岛素、HbA1c和稳态模型评估的胰岛素抵抗指数（HOMA-IR）。我们的研究结果表明，暴露于VOCs与老年人T2D患病几率增加有关，这可能是由葡萄糖稳态受损介导的。减少VOCs暴露应成为旨在减轻2型糖尿病负担的公共卫生策略的必要组成部分。
