Chan Fiona K I, Moraga Maria-Teresa, Habib Bettina, Girard Nadyne, Boulet John R, Tamblyn Robyn
Department of Epidemiology, Biostatistics, and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Clinical and Health Informatics Research Group, McGill University, Montreal, Quebec, Canada.
Pharmacoepidemiol Drug Saf. 2024 Dec;33(12):e70068. doi: 10.1002/pds.70068.
The objective of this study is to estimate the association between physician's age, sex, clinical and communication competencies, and cultural background on benzodiazepines and Z-drugs (BDZ) prescribing to older adults with insomnia.
A cohort of international medical graduates (IMGs) who completed their pre-residency licensure exam in 1998-2004 were linked to all U.S. Medicare patients they provided care to in 2014-2015. Their care records in Parts A, B, and D from all physicians were extracted. The first outpatient visit for insomnia to a study IMG was identified for each patient in that period. The outcome was incident BDZ prescribing by the study physician following the visit. Main exposures were physician age, sex, citizenship at birth, and clinical and communication competency as measured on the licensure exam. The association between physician characteristics and BDZ prescribing, adjusting for physician and patient covariates, was estimated using generalized estimating equations multivariable logistic regression.
We analyzed 28 018 patients seen by 4069 unique physicians. IMGs born in all other regions of the world were less likely to prescribe BDZs compared to U.S.-born IMGs, with physicians from the United Kingdom being least likely (OR 0.54 [95%CI 0.34-0.85]). Neither physician's clinical competency nor communication ability were associated with BDZ prescribing (OR per 10% increase, respectively: 0.95 [95%CI 0.88-1.02] and 0.98 [95%CI 0.93-1.04]). Older physicians remain more likely to prescribe BDZ (OR per 5-year increase 1.04 [95%CI 1.00-1.08]).
The associations between cultural background and physician's age on BDZ prescribing highlight the potential targets for remedial solutions to reduce the use of potentially inappropriate medications.
本研究的目的是评估医生的年龄、性别、临床和沟通能力以及文化背景与给老年失眠患者开具苯二氮䓬类药物和Z类药物(BDZ)之间的关联。
一组在1998 - 2004年完成住院前执照考试的国际医学毕业生(IMGs)与他们在2014 - 2015年为其提供护理的所有美国医疗保险患者进行了关联。提取了所有医生在A、B和D部分的护理记录。在此期间为每位患者确定了首次因失眠就诊于研究IMG的门诊就诊情况。结果是研究医生在就诊后开具BDZ的情况。主要暴露因素是医生的年龄、性别、出生时的国籍以及执照考试中衡量的临床和沟通能力。使用广义估计方程多变量逻辑回归估计医生特征与BDZ处方之间的关联,并对医生和患者的协变量进行调整。
我们分析了由4069名不同医生诊治的28018名患者。与在美国出生的IMG相比,出生在世界其他所有地区的IMG开具BDZ的可能性较小,来自英国的医生可能性最小(比值比0.54 [95%置信区间0.34 - 0.85])。医生的临床能力和沟通能力均与BDZ处方无关(每增加10%的比值比分别为:0.95 [95%置信区间0.88 - 1.02]和0.98 [95%置信区间0.93 - 1.04])。年龄较大的医生开具BDZ的可能性仍然更高(每增加5岁的比值比为1.04 [95%置信区间1.00 - 1.08])。
文化背景和医生年龄与BDZ处方之间的关联突出了减少潜在不适当药物使用的补救措施的潜在目标。