Olanrewaju Moronkeji Temitope, Olanrewaju Olatutu Ololade, Ibrahim Azeez Oyemomi, Ipinnimo Tope Michael, Ajayi Paul Oladapo, Sito Oluwafunmilayo Kehinde
Department of Family Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria.
Department of Pharmacy, Federal Teaching Hospital, Ido-Ekiti, Nigeria.
Niger Postgrad Med J. 2024 Oct 1;31(4):290-298. doi: 10.4103/npmj.npmj_176_24. Epub 2024 Dec 4.
Previous studies have been conducted on medication adherence in Southwest Nigeria, but none of these has reported the relationship between highly active antiretroviral therapy (HAART) adherence, spirituality and viral load (VL) amongst people living with Human immunodeficiency virus (HIV)/AIDS, especially in rural settings of Southwestern Nigeria. This study assessed the pattern of medication adherence, spirituality and VL and ascertained the association of socio-demographics and spirituality on medication adherence amongst patients on HAART in rural Southwestern Nigeria.
A hospital-based cross-sectional study involving 321 consented patients on HAART who were recruited by systematic sampling technique at the adult HIV clinic. Data were collected using an interviewer-administered questionnaire that assessed participants' socio-demographic profiles, medication adherence and spirituality. Their blood samples were collected and their VLs were determined. The data were analysed using SPSS version 20. Logistic regression was done to identify the independent predictors of medication adherence.
The majority of the respondents reported a medium level of medication adherence (66.4%), a high level of spirituality (68.8%) and a low level of VL (67.3%). Amongst variables that had a statistically significant association with medication adherence were being educated, married, divorced, separated or widowed (P < 0.05). Furthermore, persons with high spirituality were 2.6 times more likely to be adherent to antiretroviral drugs when compared to persons with low spirituality (P < 0.05).
It was shown that high spirituality is a positive predictor of medication adherence amongst patients on HAART. It, therefore, suggests that efforts deployed to improve the spirituality of these patients would most likely improve their medication adherence.
此前已针对尼日利亚西南部的药物依从性开展了多项研究，但这些研究均未报告高效抗逆转录病毒疗法（HAART）依从性、精神信仰与人类免疫缺陷病毒（HIV）/艾滋病感染者病毒载量（VL）之间的关系，尤其是在尼日利亚西南部的农村地区。本研究评估了药物依从性、精神信仰和病毒载量的模式，并确定了尼日利亚西南部农村地区接受HAART治疗的患者的社会人口统计学特征和精神信仰与药物依从性之间的关联。
一项基于医院的横断面研究，涉及321名同意参与的接受HAART治疗的患者，这些患者是在成人HIV诊所通过系统抽样技术招募的。使用由访谈员实施的问卷收集数据，该问卷评估了参与者的社会人口统计学特征、药物依从性和精神信仰。采集他们的血样并测定病毒载量。使用SPSS 20版对数据进行分析。进行逻辑回归以确定药物依从性的独立预测因素。
大多数受访者报告药物依从性处于中等水平（66.4%），精神信仰水平较高（68.8%），病毒载量水平较低（67.3%）。在与药物依从性有统计学显著关联的变量中，包括受过教育、已婚、离异、分居或丧偶（P < 0.05）。此外，与精神信仰低的人相比，精神信仰高的人坚持服用抗逆转录病毒药物的可能性高2.6倍（P < 0.05）。
研究表明，精神信仰高是接受HAART治疗患者药物依从性的积极预测因素。因此，这表明为提高这些患者的精神信仰所做的努力很可能会改善他们的药物依从性。
