Sajadi Sayed Mohammad Javad, Tamizifar Babak, Sanei Mohammad Hossein, Babak Anahita
Department of internal medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2024 Sep 30;29:59. doi: 10.4103/jrms.jrms_813_22. eCollection 2024.
Primary biliary cholangitis (PBC) can impact both the quality of life and the survival of patients. The study aimed to determine the survival rate and associated variables in patients with PBC.
This cohort research comprised 65 patients diagnosed with PBC who were admitted to the pathology section between January 2010 and December 2019. Survival was determined by reviewing hospital medical data and following up with the patients. The impact of demographic factors, clinical, laboratory, and histopathological aspects on patient survival time was investigated using Kaplan-Meier survival analysis and Cox regression.
The average period of follow-up was 6.25 years with a standard deviation of 3.2 years. In surviving patients, the baseline bilirubin level was 2.83, but in deceased or transplanted patients, it was 8.95 ( = 0.002). The baseline albumin level was 3.99 in surviving patients and 3.66 in deceased or transplanted patients ( = 0.024). The incidence of cirrhosis in those who survived was 1.8%, but in patients who died or underwent a transplant, it was 40%. Out of 65 cases, 3 patients (4.7%) died and 7 (10%) had liver transplants. Survival rates of patients vary based on factors such as jaundice ( = 0.002), weariness ( = 0.03), cirrhosis ( < 0.001), and vitiligo ( = 0.033). There were notable variations in the average Mayo score between the two groups of patients who had liver transplantation and survived, with scores of 7.21 and 5.61, respectively.
The study found that aspartate aminotransferase and alanine aminotransferase levels, baseline and final bilirubin, albumin, antinuclear antibody, the presence of cirrhosis, and jaundice significantly influenced patient survival with PBC.
原发性胆汁性胆管炎（PBC）会影响患者的生活质量和生存率。本研究旨在确定PBC患者的生存率及相关变量。
这项队列研究纳入了2010年1月至2019年12月间收治于病理科的65例确诊为PBC的患者。通过查阅医院医疗数据并对患者进行随访来确定生存率。使用Kaplan-Meier生存分析和Cox回归研究人口统计学因素、临床、实验室及组织病理学方面对患者生存时间的影响。
平均随访期为6.25年，标准差为3.2年。存活患者的基线胆红素水平为2.83，但死亡或接受移植的患者为8.95（P = 0.002）。存活患者的基线白蛋白水平为3.99，死亡或接受移植的患者为3.66（P = 0.024）。存活者中肝硬化的发生率为1.8%，但死亡或接受移植的患者中为40%。65例患者中，3例（4.7%）死亡，7例（10%）接受了肝移植。患者的生存率因黄疸（P = 0.002）、疲劳（P = 0.03）、肝硬化（P < 0.001）和白癜风（P = 0.033）等因素而异。接受肝移植并存活的两组患者的平均梅奥评分存在显著差异，分别为7.21和5.61。
研究发现，天冬氨酸转氨酶和丙氨酸转氨酶水平、基线和最终胆红素、白蛋白、抗核抗体、肝硬化的存在以及黄疸对PBC患者的生存有显著影响。
