甘油三酯与高密度脂蛋白胆固醇的比值与围产期心肌病风险增加相关。

The triglyceride-to-high-density lipoprotein cholesterol ratio is associated with an increased risk of peripartum cardiomyopathy.

作者信息

Chen Naiyi, Xiao Jie, Luo Yijie, Fu Kang, Sun Ziru, Zhang Xinyu, Liu Yanan, Lu Huixia, Ji Xiaoping

机构信息

The Key Laboratory of Cardiovascular Remodeling and Function Research, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Shandong University, Jinan, China.

Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China.

出版信息

Front Endocrinol (Lausanne). 2024 Nov 19;15:1447791. doi: 10.3389/fendo.2024.1447791. eCollection 2024.

DOI:10.3389/fendo.2024.1447791

PMID:39629048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11611594/

Abstract

BACKGROUND

Peripartum cardiomyopathy (PPCM) is a form of heart failure that severely affects women during the late stages of pregnancy and in the postpartum period. Currently, the diagnosis of PPCM is not fully understood and is likely multifactorial. Abnormal lipid metabolism plays an important role in the onset of cardiovascular diseases, especially in patients with heart failure. Moreover, animal experiments have confirmed a possible association between abnormal lipid metabolism and PPCM onset. However, clinical evidence is currently lacking, and reliable and effective indicators for predicting the onset of PPCM are insufficient. The ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) is a novel metabolic marker that is associated with the risk of coronary heart disease. However, the relationship between the TG/HDL-C ratio and the risk of PPCM in parturients remains unknown. Therefore, this study aimed to explore the role of the TG/HDL-C ratio in predicting the risk of PPCM.

METHODS

This study included 600 parturients hospitalized at Qilu Hospital of Shandong University between January 2010 and August 2023 (150 patients with PPCM and 450 healthy parturients). The TG/HDL-C ratio was calculated as triglyceride levels (mmol/L)/high-density lipoprotein cholesterol levels (mmol/L). The relationship between the TG/HDL-C ratio and PPCM was analyzed using logistic regression analysis and receiver operating characteristic curve analysis.

RESULTS

Significant differences were observed in the TG/HDL-C ratio between patients with PPCM and healthy parturients. The TG/HDL-C ratio was higher in patients with PPCM than in healthy parturients ( < 0.001). Logistic regression analysis revealed that the TG/HDL-C ratio increased the risk of PPCM and had predictive accuracy for the onset of PPCM (odds ratio, 1.249; 95% confidence interval, 1.004-1.553; = 0.046). Moreover, the TG/HDL-C ratio was positively correlated with the NT-proBNP levels at the onset of PPCM ( = 0.081, = 0.008).

CONCLUSIONS

A higher TG/HDL-C ratio was significantly associated with the risk of PPCM.

摘要

背景

围产期心肌病（PPCM）是一种心力衰竭形式，在妊娠晚期和产后严重影响女性。目前，PPCM的诊断尚未完全明确，可能是多因素的。脂质代谢异常在心血管疾病的发生中起重要作用，尤其是在心力衰竭患者中。此外，动物实验已证实脂质代谢异常与PPCM发病之间可能存在关联。然而，目前缺乏临床证据，且预测PPCM发病的可靠有效指标不足。甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）是一种与冠心病风险相关的新型代谢标志物。然而，TG/HDL-C比值与产妇PPCM风险之间的关系尚不清楚。因此，本研究旨在探讨TG/HDL-C比值在预测PPCM风险中的作用。

方法

本研究纳入了2010年1月至2023年8月在山东大学齐鲁医院住院的600例产妇（150例PPCM患者和450例健康产妇）。TG/HDL-C比值计算为甘油三酯水平（mmol/L）/高密度脂蛋白胆固醇水平（mmol/L）。采用逻辑回归分析和受试者工作特征曲线分析TG/HDL-C比值与PPCM之间的关系。

结果

PPCM患者与健康产妇的TG/HDL-C比值存在显著差异。PPCM患者的TG/HDL-C比值高于健康产妇（<0.001）。逻辑回归分析显示，TG/HDL-C比值增加了PPCM的风险，对PPCM发病具有预测准确性（优势比，1.249；95%置信区间，1.004-1.553；=0.046）。此外，TG/HDL-C比值与PPCM发病时的NT-proBNP水平呈正相关（=0.081，=0.008）。