Chen Yu-Wen, Wu Chun-Ying, Chen Yi-Ju
Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan.
Institute of Biomedical Informatics, Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
JAAD Int. 2024 Sep 27;18:62-68. doi: 10.1016/j.jdin.2024.08.022. eCollection 2025 Feb.
The gut-skin-brain axis has been long postulated in acne vulgaris. Few studies focused on bowel habits in patients with acne vulgaris have yielded controversial results.
To examine the relationship between acne vulgaris and gastrointestinal comorbidities.
We conducted a nationwide case-control study using data from the Taiwan National Health Insurance Research Database spanning the years 1997 to 2013. Acne vulgaris and the control group were stratified by age, and we examined the association of gastrointestinal comorbidities across different age, sex, and antibiotic use through conditional logistic regression analysis.
A total of 185,491 patients with acne vulgaris were identified. The primary demographic for acne vulgaris comprised adolescents, followed by adult-onset groups, with a female predominance observed across all age subgroups. Patients with acne vulgaris exhibited a significantly elevated risk of developing gastrointestinal comorbidities, including peptic ulcers, irritable bowel syndrome, gastroenteritis, gastroesophageal reflux disease, and constipation. This increased risk was particularly notable in patients aged ≥12 years, and those with moderate-to-severe acne.
Miscoding and misclassification might have occurred.
Patients with Acne vulgaris have higher risks of gastrointestinal comorbidities. For patients with moderate-to-severe acne, gastroenterology specialty consultation may be warranted.
长期以来，寻常痤疮中一直存在肠-皮肤-脑轴的假说。很少有针对寻常痤疮患者肠道习惯的研究得出了有争议的结果。
研究寻常痤疮与胃肠道合并症之间的关系。
我们利用1997年至2013年台湾全民健康保险研究数据库的数据进行了一项全国性病例对照研究。寻常痤疮组和对照组按年龄分层，我们通过条件逻辑回归分析研究了不同年龄、性别和抗生素使用情况下胃肠道合并症的相关性。
共识别出185491例寻常痤疮患者。寻常痤疮的主要人群为青少年，其次是成年发病组，在所有年龄亚组中均观察到女性占主导地位。寻常痤疮患者发生胃肠道合并症的风险显著升高，包括消化性溃疡、肠易激综合征、肠胃炎、胃食管反流病和便秘。这种风险增加在≥12岁的患者以及中重度痤疮患者中尤为明显。
可能存在编码错误和分类错误。
寻常痤疮患者发生胃肠道合并症的风险更高。对于中重度痤疮患者，可能需要胃肠病专科会诊。
