微小RNA在膀胱癌无创诊断中的作用：一项系统综述
The role of microRNAs in non-invasive diagnosis of bladder cancer: a systematic review.
作者信息
de Sousa Neto Pedro Ivo, Pinto Vicktor Bruno Pereira, Piancó Elaine Dos Santos, Gomes Malene Lima, Monteiro Sally Cristina Moutinho, Vidal Flávia Castello Branco, Nascimento Maria do Desterro Soares Brandão, Pinho Jaqueline Diniz, Calixto José de Ribamar Rodrigues, de Andrade Marcelo Souza
机构信息
Adult Health Postgraduate Program, Universidade Federal do Maranhão, São Luís, MA, Brazil.
Zé Doca Center for Higher Studies, Universidade Estadual do Maranhão, Zé Doca, MA, Brazil.
出版信息
Einstein (Sao Paulo). 2024 Nov 29;22:eRW0611. doi: 10.31744/einstein_journal/2024RW0611. eCollection 2024.
OBJECTIVE
MicroRNAs are small non-coding RNAs that are abundantly expressed in various biofluids, making them promising candidates for cancer biomarkers. This review aims to present current evidence on the use of miRNA as biomarkers for the non-invasive diagnosis of bladder cancer.
METHODS
A systematic literature review, using the Medline database, was performed in July 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All articles were required to satisfy the risk-of-bias assessment using the Joanna Briggs Institute Critical Assessment Tools. Data were collected based on miRNA expression, sample type, expression profiles, and accuracy.
RESULTS
The initial search retrieved 437 studies, 21 of which were included in the final analysis. Most studies on miRNA expression in human fluids used urine samples for analysis.
CONCLUSION
There is a trend to cluster the expressed miRNAs to build diagnostic panels or use them in association with other diagnostic methods to achieve reasonable accuracy.Prospero database registration: (https://www.crd.york.ac.uk/prospero/) under ID CRD42022351686.
目的
微小RNA是一类小的非编码RNA，在多种生物流体中大量表达，使其成为癌症生物标志物的有潜力的候选者。本综述旨在呈现关于使用微小RNA作为膀胱癌非侵入性诊断生物标志物的当前证据。
方法
根据系统评价与Meta分析的首选报告项目指南，于2022年7月使用Medline数据库进行了系统文献综述。所有文章都需要使用乔安娜·布里格斯研究所的关键评估工具进行偏倚风险评估。基于微小RNA表达、样本类型、表达谱和准确性收集数据。
结果
初步检索获得437项研究，其中21项纳入最终分析。大多数关于人体流体中微小RNA表达的研究使用尿液样本进行分析。
结论
存在将表达的微小RNA聚类以构建诊断面板或与其他诊断方法联合使用以实现合理准确性的趋势。Prospero数据库注册：（https://www.crd.york.ac.uk/prospero/），标识符为CRD42022351686。
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