Guven Ali E, Zadeh Arman T, Chiapparelli Erika, Evangelisti Gisberto, Köhli Paul, Burkhard Marco D, Hambrecht Jan, Tsuchiya Koki, Amoroso Krizia, Zhu Jiaqi, Shue Jennifer, Cammisa Frank P, Hughes Alexander P
Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, New York, USA.
Department of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, New York, USA; Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
World Neurosurg. 2025 Feb;194:123530. doi: 10.1016/j.wneu.2024.11.113. Epub 2024 Dec 26.
Lumbar interbody fusion is a well-established surgical technique for treating various lumbar degenerative pathologies. Expandable cages have been introduced to allow for insertion via the confined access and to improve disc height restoration, although concerns about the stability of the screw-based cages in the expanded state remain a concern. This study aims to evaluate the short-term clinical and radiographic outcomes of a novel nonscrew-based expandable transforaminal lumbar interbody fusion cage.
Adult patients who underwent posterior spinal fusion and were implanted the X-PAC transforaminal lumbar interbody fusion cage for degenerative lumbar conditions between September 2021 and April 2023 were retrospectively reviewed. Radiographic outcomes, including anterior disc height (ADH), posterior disc height (PDH), and segmental lordosis, were measured preoperatively, postoperatively, and at ≥6-month follow-up. Cage subsidence at follow-up was assessed according to the Marchi classification, along with cage collapse and complications requiring revision surgery. Radiographic outcomes were compared between time points using Wilcoxon signed-rank tests and paired t-test depending on distribution.
The study included 131 patients, implanted with 160 expandable cages. Significant increases in ADH and PDH were observed postoperatively and maintained at follow-up (ADH: 9.8 mm ± 5.4 vs. 12.7 mm ± 4.0, and PDH: 3.1 mm [1.3-4.9] vs. 5.0 mm [3.6-6.9], respectively, P < 0.001). Segmental lordosis showed an initial postoperative increase but was not significantly sustained at the 6-month follow-up. Cage subsidence was seen in 9.3% of cases, with no severe subsidence or complete cage collapse. Revision surgery was required in 6.1% of patients, none due to cage-related issues.
The novel nonscrew-based expandable cage effectively restored and maintained disc height with a low incidence of complications, suggesting it as a safe and effective alternative for lumbar interbody fusion. Further long-term studies are needed to confirm its efficacy and safety.
腰椎椎间融合术是一种成熟的外科技术,用于治疗各种腰椎退行性病变。可扩张椎间融合器已被引入,以允许通过有限的入路进行植入,并改善椎间盘高度恢复,尽管对基于螺钉的椎间融合器在扩张状态下的稳定性仍存在担忧。本研究旨在评估一种新型非螺钉式可扩张经椎间孔腰椎椎间融合器的短期临床和影像学结果。
回顾性分析2021年9月至2023年4月间因腰椎退行性疾病接受后路脊柱融合术并植入X-PAC经椎间孔腰椎椎间融合器的成年患者。术前、术后及随访≥6个月时测量影像学结果,包括前椎间盘高度(ADH)、后椎间盘高度(PDH)和节段性前凸。根据马尔基分类法评估随访时椎间融合器的下沉情况,以及椎间融合器塌陷和需要翻修手术的并发症。根据分布情况,使用Wilcoxon符号秩检验和配对t检验比较不同时间点的影像学结果。
该研究纳入131例患者,植入160个可扩张椎间融合器。术后观察到ADH和PDH显著增加,并在随访时保持(ADH:分别为9.8mm±5.4与12.7mm±4.0,PDH:3.1mm[1.3 - 4.9]与5.0mm[3.6 - 6.9],P<0.001)。节段性前凸术后最初增加,但在6个月随访时未显著维持。9.3%的病例出现椎间融合器下沉,无严重下沉或完全椎间融合器塌陷。6.1%的患者需要翻修手术,无一例是由于椎间融合器相关问题。
新型非螺钉式可扩张椎间融合器能有效恢复并维持椎间盘高度,并发症发生率低,表明它是腰椎椎间融合的一种安全有效的替代方法。需要进一步的长期研究来证实其有效性和安全性。