Yao Jiayu, Zhang Youtao, Wang Ziwen, Chen Yuejun, Shi Xingjuan
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China.
J Cell Physiol. 2025 Jan;240(1):e31496. doi: 10.1002/jcp.31496. Epub 2024 Dec 4.
Various cells such as cardiomyocytes, fibroblasts and endothelial cells constitute integral components of cardiac tissue. The health and stability of cardiac ecosystem are ensured by the action of a certain type of cell and the intricate interactions between multiple cell types. The dysfunctional cells exert a profound impact on the development of cardiovascular diseases by involving in the pathological process. In this paper, we introduce the dynamic activity, cell surface markers as well as biological function of the various cells in the heart. Besides, we discuss the multiple signaling pathways involved in the cardiac injury including Hippo/YAP, TGF-β/Smads, PI3K/Akt, and MAPK signaling. The complexity of different cell types poses a great challenge to the disease treatment. By characterizing the roles of various cell types in cardiovascular diseases, we sought to discuss the potential strategies for preventing and treating cardiovascular diseases.
各种细胞，如心肌细胞、成纤维细胞和内皮细胞，构成了心脏组织的重要组成部分。心脏生态系统的健康和稳定通过某种类型细胞的作用以及多种细胞类型之间复杂的相互作用来确保。功能失调的细胞通过参与病理过程对心血管疾病的发展产生深远影响。在本文中，我们介绍了心脏中各种细胞的动态活性、细胞表面标志物以及生物学功能。此外，我们讨论了参与心脏损伤的多种信号通路，包括Hippo/YAP、TGF-β/Smads、PI3K/Akt和MAPK信号通路。不同细胞类型的复杂性给疾病治疗带来了巨大挑战。通过阐明各种细胞类型在心血管疾病中的作用，我们试图探讨预防和治疗心血管疾病的潜在策略。
