Tao Honglei, Li Lei, Li Huiling, Ma Tingting, Zhu Xinping, Cao Jili, Zhu Yongqiang, Zhu Shengmei, Li Mingqian
Department of Anesthesiology, The First Affiliated Hospital, ZheJiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.
Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
Sci Rep. 2024 Dec 4;14(1):30194. doi: 10.1038/s41598-024-81912-y.
Cancer is one of the leading causes of morbidity and mortality in the global population. The effective management of cancer-associated pain and anesthesia are critical aspects of comprehensive cancer treatment. However, the role and mechanism of anesthesia and analgesia-related drugs in tumors remain controversial. In this study, the efficacy of 16 commonly used analgesics and anesthetics against non-small cell lung cancer (NSCLC) was evaluated. Among the 16 examined injections, butorphanol tartrate injection significantly inhibited the proliferation of NSCLC cells and increased the sensitivity of the EGFR-TKI-resistant H1975 cell line to gefitinib. Benzethonium chloride (BC) is the main active antitumor ingredient of butorphanol tartrate injection. BC may regulate the cell cycle, apoptosis and EMT signaling pathways by modulating the P53 signaling pathway. Our study reveals the therapeutic value of butorphanol tartrate injection and BC in the treatment of NSCLC and provides a theoretical basis for comprehensive therapies for NSCLC.
癌症是全球人口发病和死亡的主要原因之一。癌症相关疼痛的有效管理和麻醉是综合癌症治疗的关键方面。然而，麻醉和镇痛相关药物在肿瘤中的作用和机制仍存在争议。在本研究中，评估了16种常用镇痛药和麻醉药对非小细胞肺癌（NSCLC）的疗效。在所检测的16种注射剂中，酒石酸布托啡诺注射液显著抑制NSCLC细胞的增殖，并增加EGFR-TKI耐药的H1975细胞系对吉非替尼的敏感性。苯扎氯铵（BC）是酒石酸布托啡诺注射液的主要活性抗肿瘤成分。BC可能通过调节P53信号通路来调节细胞周期、凋亡和EMT信号通路。我们的研究揭示了酒石酸布托啡诺注射液和BC在NSCLC治疗中的治疗价值，并为NSCLC的综合治疗提供了理论依据。
Zotero 插件
