Satria Fauzi Budi, Tsai Feng-Jen
Philosophy Doctor in Medicine Programme, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Department of Community Medicine, Faculty of Medicine and Health, Universitas Sumatera Utara, Medan, Indonesia.
Sci Rep. 2024 Dec 4;14(1):30184. doi: 10.1038/s41598-024-80984-0.
Antimicrobial resistance (AMR) is a growing global concern, compromising the effectiveness of treatments for infections and being referred to as a silent pandemic. This study examines the factors associated with AMR awareness and capacities across 103 countries from 2017 to 2020. This cross-sectional study aimed to determine whether factors such as Human Development Index (HDI), Civil Liberties (CL), Gender Equality (GE), Universal Health Coverage (UHC), Healthcare Workforce Density (HWD), and State Party Self-Assessment Annual Report (SPAR) scores are significantly associated with countries' AMR awareness and capacities. The results identified that the majority of countries had Very High HDI, Full Freedom, Fair GE, Low UHC, High HWD, and Low SPAR scores. However, despite these generally favorable profiles, the majority still lack sufficient awareness and capacity to address AMR. This underscores the importance of strengthening AMR awareness and capacities globally, regardless of a country's characteristics. Significant associations were observed between these factors and AMR awareness and capacities (χ). UHC emerged as the only factor significantly associated with AMR capacities, where countries with low AMR capacities are more frequently found among countries that also have poor UHC (OR = 10.49, 8.96, and 12.92 across various models; all p < 0.05). This finding highlights the potential to improve the AMR capacities of countries through the achievement of UHC targets.
抗菌药物耐药性(AMR)是一个日益引起全球关注的问题,它损害了感染治疗的有效性,被称为一场无声的大流行。本研究调查了2017年至2020年期间103个国家与AMR意识和能力相关的因素。这项横断面研究旨在确定人类发展指数(HDI)、公民自由(CL)、性别平等(GE)、全民健康覆盖(UHC)、医疗劳动力密度(HWD)和缔约国自我评估年度报告(SPAR)得分等因素是否与各国的AMR意识和能力显著相关。结果发现,大多数国家的人类发展指数非常高、享有充分自由、性别平等状况良好、全民健康覆盖水平低、医疗劳动力密度高、缔约国自我评估年度报告得分低。然而,尽管这些总体情况较为有利,但大多数国家仍缺乏应对AMR的足够意识和能力。这凸显了在全球范围内加强AMR意识和能力的重要性,无论一个国家的特点如何。这些因素与AMR意识和能力之间存在显著关联(χ)。全民健康覆盖是唯一与AMR能力显著相关的因素,在全民健康覆盖水平较差的国家中,AMR能力较低的国家更为常见(在各种模型中,OR分别为10.49、8.96和12.92;所有p<0.05)。这一发现凸显了通过实现全民健康覆盖目标来提高各国AMR能力的潜力。