Pullens B J, Remaj B, Hedgespeth B A
Geelong Animal Referral Services, Newtown, Victoria, Australia.
Vetnostics, Mulgrave, Victoria, Australia.
Aust Vet J. 2025 Mar;103(3):112-115. doi: 10.1111/avj.13397. Epub 2024 Dec 5.
This case report describes a mycobacterial infection in an adult Whippet cross dog. The dog was diagnosed with Mycolicibacterium sediminis infection, a species of mycobacteria that is yet to be reported as a causative agent of infection in humans or domestic animals. The dog was presented for specialist opinion of a 6-month history of severe facial lymphadenopathy that was nonresponsive to antibiotic and immunosuppressive therapy. A necrotic lesion developed on her right antebrachium approximately 10-14 days before presentation. The dog was anaesthetised for computed tomography and nodule and skin biopsies including fresh tissue for mycobacterial polymerase chain reaction (PCR). The nodules contained pyogranulomatous inflammation and perivascular necrosis that are typically found in mycobacterial infections. The mycobacterial PCR isolated Mycolicibacterium sediminis. The dog was prescribed triple antibiotic therapy and tapered off corticosteroids, with noticeable improvement within 4 weeks and resolution of granulomas within 3 months of therapy. Presence of chronic dermal pyogranulomatous inflammation should raise suspicions for mycobacterial disease, and fresh tissue should be submitted for PCR to aid in diagnosis.
本病例报告描述了一只成年惠比特混血犬的分枝杆菌感染情况。这只狗被诊断为感染了栖泥分枝杆菌，该分枝杆菌菌种尚未被报道可作为人类或家畜感染的病原体。这只狗因严重面部淋巴结病已有6个月病史，对抗生素和免疫抑制治疗无反应而前来寻求专家意见。在就诊前约10 - 14天，其右前臂出现坏死性病变。这只狗接受了麻醉，进行了计算机断层扫描以及结节和皮肤活检，包括采集新鲜组织用于分枝杆菌聚合酶链反应（PCR）检测。结节中含有脓性肉芽肿性炎症和血管周围坏死，这在分枝杆菌感染中较为常见。分枝杆菌PCR检测分离出栖泥分枝杆菌。这只狗接受了三联抗生素治疗，并逐渐停用皮质类固醇，治疗4周内有明显改善，治疗3个月内肉芽肿消退。慢性皮肤脓性肉芽肿性炎症的存在应引起对分枝杆菌病的怀疑，应提交新鲜组织进行PCR检测以辅助诊断。
