Nazari-Bonab Hamideh, Nikbaf-Shandiz Mahlagha, Tutunchi Helda, Ebrahimi-Mameghani Mehrangiz
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Health Promot Perspect. 2024 Oct 31;14(3):286-296. doi: 10.34172/hpp.42549. eCollection 2024.
Oxidative stress is one of the main hits in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Propolis (PRP), a natural substance made by bees from plant extracts, has been reported to have antioxidant properties. The present clinical trial investigated the effect of Iranian PRP on prooxidant-antioxidant balance (PAB), oxidative stress biomarkers, and body composition in obese patients with NAFLD.
In the present double-blind, randomized controlled clinical trial, 44 obese patients with NAFLD were randomly allocated to either Iranian PRP (1500 mg/d) or placebo (1500 mg/d) accompanied by a calorie-restricted diet (CRD) for eight weeks. PAB, oxidative stress biomarkers, and body composition were assessed at baseline and the end of the study.
There was a significant reduction in PAB levels over the trial in both groups. However, the between-group difference was not significant at the endpoint. At the end of the study, the inter-group comparison showed a significant decrease in serum glutathione peroxidase level in the placebo group compared to the PRP group after adjusting for confounding variables based on models 1 (=0.027) and 2 (=0.028). No significant within- or between-group differences in other studied oxidative stress biomarkers were found. Moreover, no between-group differences were observed for body composition and dietary intakes of energy and antioxidant micronutrients.
Iranian PRP supplementation (1500 mg/d) for eight weeks could prevent the reduction of glutathione peroxidase levels compared to the control group. However, it could not affect other oxidative stress biomarkers, body composition, or dietary intakes of energy and antioxidant micronutrients.
氧化应激是非酒精性脂肪性肝病（NAFLD）发病机制中的主要因素之一。蜂胶（PRP）是蜜蜂从植物提取物中制成的天然物质，据报道具有抗氧化特性。本临床试验研究了伊朗蜂胶对NAFLD肥胖患者的促氧化剂 - 抗氧化剂平衡（PAB）、氧化应激生物标志物和身体成分的影响。
在本双盲、随机对照临床试验中，44名NAFLD肥胖患者被随机分配至伊朗蜂胶组（1500毫克/天）或安慰剂组（1500毫克/天），并同时进行为期八周的热量限制饮食（CRD）。在基线和研究结束时评估PAB、氧化应激生物标志物和身体成分。
两组在试验期间PAB水平均显著降低。然而，终点时组间差异不显著。研究结束时，组间比较显示，在基于模型1（=0.027）和模型2（=0.028）调整混杂变量后，安慰剂组血清谷胱甘肽过氧化物酶水平与蜂胶组相比显著降低。在其他研究的氧化应激生物标志物方面，未发现组内或组间有显著差异。此外，在身体成分以及能量和抗氧化微量营养素的饮食摄入量方面，未观察到组间差异。
与对照组相比，补充伊朗蜂胶（1500毫克/天）八周可预防谷胱甘肽过氧化物酶水平的降低。然而，它对其他氧化应激生物标志物、身体成分或能量和抗氧化微量营养素的饮食摄入量没有影响。
