Santos Ana Paula Marreilha Dos, Mateus Maria Luisa, Aschner Michael
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Phytonutrients (Karachi). 2024;3:120-135. doi: 10.62368/pn.v3i.37. Epub 2024 Oct 24.
Dietary chemoprevention has emerged as a cost-effective approach to control most prevalent chronic diseases including cancer. Changes in dietary patterns and lifestyle, such as increasing the consumption of fruits and vegetables and more balanced intakes of meat and plant foods, are a practical and effective strategy for reducing the incidence of chronic diseases. Phytonutrients (or phytochemicals) are found in eatable fruits and vegetables that, daily ingested, may exhibit a potential for modulating human metabolism in a manner favourable for the prevention of chronic and degenerative diseases. Carotenoids and flavonoids (anthocyanins, phenolic acids, polyphenols) are examples of phytonutrients. Consumption of total phytochemical intake has been consistently linked to protection from chronic diseases, including cardiovascular disease, cancer and neurodegenerative diseases. To highlight the beneficial health effects of phytonutrients in plants, we choose two interesting plants, the potato and the citrus fruits. They were chosen owing to their phytonutrient content, and low price, which makes them more easily acquired in low incoming populations, and consequently they are highly consumed not only in developing but also in developed countries. Due to its high nutrient and phytochemical content, the potato can lower oxidative stress, a key mechanism for cancer and cardiovascular disease prevention. Its phenolic compounds act as antioxidants and improve heart health. Furthermore, this review emphasizes the bioactive compounds in citrus which can reduce inflammatory mediators and reactive oxygen species generation, thus attenuating the risk of neurodegenerative diseases, cardiovascular disease, diabetes, and cancer. Besides important applications in the functional food sector, phytochemicals are also employed in the production of cosmetic and/or cosmeceutical products.
饮食化学预防已成为一种经济有效的方法,用于控制包括癌症在内的最常见慢性病。饮食模式和生活方式的改变,如增加水果和蔬菜的摄入量以及更均衡地摄入肉类和植物性食物,是降低慢性病发病率的切实有效策略。植物营养素(或植物化学物)存在于可食用的水果和蔬菜中,每日摄入这些物质可能具有以有利于预防慢性和退行性疾病的方式调节人体新陈代谢的潜力。类胡萝卜素和黄酮类化合物(花青素、酚酸、多酚)就是植物营养素的例子。总植物化学物摄入量的增加一直与预防包括心血管疾病、癌症和神经退行性疾病在内的慢性病有关。为了突出植物中植物营养素对健康的有益影响,我们选择了两种有趣的植物——土豆和柑橘类水果。选择它们是因为其植物营养素含量以及价格低廉,这使得低收入人群更容易获得,因此它们不仅在发展中国家,而且在发达国家的消费量都很高。由于土豆营养和植物化学物含量高,它可以降低氧化应激,这是预防癌症和心血管疾病的关键机制。其酚类化合物具有抗氧化作用,可改善心脏健康。此外,本综述强调了柑橘中的生物活性化合物,它们可以减少炎症介质和活性氧的产生,从而降低神经退行性疾病、心血管疾病、糖尿病和癌症的风险。除了在功能性食品领域的重要应用外,植物化学物还用于生产化妆品和/或药妆产品。