Wang Kexin, Xu Yunjian, Chen Zhenjiang, Li Huixian, Hu Rui, Qu Junle, Lu Yuan, Liu Liwei
Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province & Ministry of Education, College of Physics and Optoelectronic Engineering Shenzhen University, Shenzhen, Guangdong Province, 518060, P. R. China.
Department of Dermatology, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, and Hua Zhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong Province, 518060, P. R. China.
Nanophotonics. 2022 Oct 24;11(22):5089-5100. doi: 10.1515/nanoph-2022-0482. eCollection 2022 Dec.
Photodynamic therapy (PDT) for hypoxic tumors has attracted wide attention owing to its noninvasiveness, easy maneuverability, and instantaneity. However, hypoxia in tumors and penetration depth of conventional ultraviolet light has greatly weakened its performance. To solve these problems, under NIR-II light irradiation, squaric acid nanoparticles (SQ NPs) with superior reactive oxygen, especially, hydroxyl radicals (•OH) production performance were first utilized for hypoxic tumor therapy. SQ NPs with intense light capture capability, intense NIR emission, and excellent photobleaching resistance show continuous •OH generation capabilities under NIR-II laser excitation. Through the superior PDT performance, the growth of hypoxic tumors was effectively inhibited, and the survival rate of mice was improved. This work highlights the application of NIR-II photoexcitation in deep tissue type I photodynamic therapy of hypoxic tumors, which will facilitate the development of hypoxic tumor PDT in deep depth.
用于缺氧肿瘤的光动力疗法（PDT）因其无创性、易于操作性和即时性而备受关注。然而，肿瘤中的缺氧以及传统紫外光的穿透深度极大地削弱了其性能。为了解决这些问题，在近红外二区（NIR-II）光照射下，首次将具有优异活性氧生成性能，尤其是羟基自由基（•OH）生成性能的方酸纳米颗粒（SQ NPs）用于缺氧肿瘤治疗。具有强光捕获能力、强烈的近红外发射和优异抗光漂白性能的SQ NPs在NIR-II激光激发下表现出持续的•OH生成能力。通过卓越的光动力疗法性能，有效抑制了缺氧肿瘤的生长，并提高了小鼠的存活率。这项工作突出了NIR-II光激发在缺氧肿瘤深部组织I型光动力疗法中的应用，这将推动深部缺氧肿瘤光动力疗法的发展。
