Liu Quan, Xie Zhongjian, Qiu Meng, Shim Inseob, Yang Yunlong, Xie Sisi, Yang Qinhe, Wang Dou, Chen Shiyou, Fan Taojian, Ding Bo, Guo Ziheng, Adah Dickson, Yao Xinhuang, Zhang Yuhua, Wu Hong, Wu Zongze, Wei Chaoying, Wang Hongzhong, Kim Hyeong Seok, Zou Qingshuang, Yan Qiaoting, Cai Zhen, Kim Jong Seung, Liu Li-Ping, Zhang Han, Cao Yihai
Department of Hepatobiliary and Pancreas Surgery The 2nd Clinical Medical College (Shenzhen People's Hospital) of Jinan University Shenzhen 518020 P. R. China.
Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan University Guangzhou Guangdong 510632 P. R. China.
Adv Sci (Weinh). 2020 Nov 5;7(24):2001191. doi: 10.1002/advs.202001191. eCollection 2020 Dec.
Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.
传统化疗和光热疗法（PTT）面临许多重大挑战，包括全身毒性、低生物利用度、组织穿透性差、化疗/热疗诱导的炎症以及肿瘤血管生成。一种多功能纳米药物为克服上述限制并成功转化为临床实践提供了令人兴奋的机会。在此，基于碳化锆（ZrC）纳米片作为深部PTT光敏剂和按需设计的抗癌前药SN38-Nif开发了一种有前景的生物光子纳米平台，该前药通过光热疗法和肿瘤过表达的酯酶释放并激活。体外和体内实验证据表明，集成的ZrC@前药生物光子纳米平台通过特异性靶向恶性细胞、化疗/热疗诱导的肿瘤炎症和血管生成，具有强大的抗癌作用。在小鼠模型中，ZrC@前药系统显著抑制肿瘤复发、转移、炎症和血管生成。这些发现揭示了一种有前景的生物光子策略用于癌症的精准治疗。
