Al Ghafri Mohammed H, Al Toubi Sumaiyah O, Maddali Madan M, Sathiya Panchatcharam M, Jose Sachin, Al-Kindi Hamood N
Department of Pediatric Intensive Care, Royal Hospital, Muscat, Oman.
Department of Oman Medical Specialty Board, Muscat, Oman.
Sultan Qaboos Univ Med J. 2024 Nov;24(4):540-547. doi: 10.18295/squmj.11.2024.077. Epub 2024 Nov 27.
This study primarily aimed to compare the mechanical ventilation durations between pulmonary valve-sparing and transannular patch repair techniques in the surgical correction of Tetralogy of Fallot. Secondary objectives included comparison of demographic characteristics, cardiopulmonary bypass parameters, postoperative vasoactive inotrope requirements, incidence of cardiac conduction abnormalities, echocardiographic findings, intensive care unit and hospitalisation durations, reoperations rates, morbidity and mortality between the 2 approaches.
This retrospective cohort study was conducted at the Royal Hospital, Muscat, Oman, between January 2016 and December 2019. This study included 102 paediatric patients who underwent complete surgical correction of Tetralogy of Fallot over 3 years, either by a pulmonary valve-sparing technique (Group 1, n = 43) or by transannular patch repair (Group 2, n = 59). Data for both primary and secondary outcomes were extracted from hospital records.
Mechanical ventilation duration was significantly shorter in Group 1 ( = 0.039). Patients in Group 1 were generally older, with shorter cardiopulmonary bypass and aortic clamp times, lower inotrope scores, and shorter chest tube retention, intensive care unit and hospitalisation periods. Junctional ectopic tachycardia and severe pulmonary regurgitation were significantly more common in Group 2, while right ventricular outflow tract peak pressure gradients were higher in Group 1. Multivariate analysis identified patient weight as the only independent predictor of mechanical ventilation duration.
Pulmonary valve preservation was associated with better early outcomes, including reduced mechanical ventilation duration, lower vasoactive inotrope scores, decreased postoperative arrhythmias and shorter hospital stay.
本研究主要旨在比较法洛四联症外科矫治中保留肺动脉瓣技术与跨环补片修复技术之间的机械通气时长。次要目的包括比较两种方法在人口统计学特征、体外循环参数、术后血管活性正性肌力药物需求、心脏传导异常发生率、超声心动图检查结果、重症监护病房住院时长和住院总时长、再次手术率、发病率及死亡率方面的差异。
这项回顾性队列研究于2016年1月至2019年12月在阿曼马斯喀特的皇家医院开展。本研究纳入了102例在3年期间接受法洛四联症完全外科矫治的儿科患者,这些患者采用保留肺动脉瓣技术(第1组,n = 43)或跨环补片修复(第2组,n = 59)。主要和次要结局的数据均从医院记录中提取。
第1组的机械通气时长显著更短( = 0.039)。第1组患者一般年龄更大,体外循环和主动脉阻断时间更短,正性肌力评分更低,胸管留置时间、重症监护病房住院时间和住院总时长更短。交界性异位性心动过速和重度肺动脉反流在第2组中显著更常见,而第1组的右心室流出道峰值压力梯度更高。多因素分析确定患者体重是机械通气时长的唯一独立预测因素。
保留肺动脉瓣与更好的早期结局相关,包括缩短机械通气时长、降低血管活性正性肌力评分、减少术后心律失常及缩短住院时间。