Increased incidence of uterine leiomyoma in young females with depression: An observational study.

Based on analyses of 22,487,947 person-years of follow-up data in a cohort of 2,523,565 young females, we found that the presence of depression was associated with a higher cumulative incidence of new-onset uterine leiomyoma than the absence of depression. This risk was even higher in patients with recurrent depression, and depression had a significant interaction with relatively old age and dyslipidemia. Screening for uterine leiomyoma is advisable in young females experiencing depression, as they appear to be at increased risk for developing this tumor type.