Oxford Brain Health Clinical Trials Unit, University of Oxford, Oxford, UK.
Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Womens Health (Lond). 2021 Jan-Dec;17:17455065211019717. doi: 10.1177/17455065211019717.
It is important to evaluate sequalae for complex chronic health conditions such as endometriosis and mental health disorders. Endometriosis impacts 1 in 10 women. Mental health outcomes can be a primary determinant in many physical health conditions although this is an area not well researched particularly in women's health. This has been problematic for endometriosis patients in particular, who report mental health issues as well as other key comorbidities such as chronic pelvic pain and infertility. This could be partly due to the complexities associated with comprehensively exploring overlaps between physical and mental health disorders in the presence of multiple comorbidities and their potential mechanistic relationship.
In this evidence synthesis, a systematic methodology and mixed-methods approaches were used to synthesize both qualitative and quantitative data to examine the prevalence of the overlapping sequalae between endometriosis and psychiatric symptoms and disorders. As part of this, an evidence synthesis protocol was developed which included a systematic review protocol that was published on PROSPERO (CRD42020181495). The aim was to identify and evaluate mental health reported outcomes and prevalence of symptoms and psychiatric disorders associated with endometriosis.
A total of 34 papers were included in the systematic review and 15 were included in the meta-analysis. Anxiety and depression symptoms were the most commonly reported mental health outcomes while a pooled analysis also revealed high prevalence of chronic pelvic pain and dyspareunia.
It is evident that small-scale cross-sectional studies have been conducted in a variety of settings to determine mental health outcomes among endometriosis patients. Further research is required to comprehensively evaluate the mental health sequalae with endometriosis.
评估子宫内膜异位症和心理健康障碍等复杂慢性健康状况的后遗症非常重要。子宫内膜异位症影响十分之一的女性。心理健康结果可能是许多身体健康状况的主要决定因素，尽管这在女性健康领域的研究还不够充分。这对子宫内膜异位症患者来说尤其成问题，他们报告了心理健康问题以及其他主要合并症，如慢性盆腔疼痛和不孕。这可能部分是由于在存在多种合并症及其潜在的机制关系的情况下，全面探讨身体和心理健康障碍之间的重叠所带来的复杂性所致。
在这项证据综合中，采用系统方法和混合方法来综合定性和定量数据，以检查子宫内膜异位症和精神症状和障碍之间重叠后遗症的患病率。作为其中的一部分，制定了一项证据综合方案，其中包括在 PROSPERO（CRD42020181495）上发表的系统评价方案。目的是确定和评估与子宫内膜异位症相关的心理健康报告结果以及症状和精神障碍的患病率。
共有 34 篇论文被纳入系统评价，其中 15 篇论文被纳入荟萃分析。焦虑和抑郁症状是最常报告的心理健康结果，而汇总分析还显示慢性盆腔疼痛和性交困难的高患病率。
显然，已经在各种环境中进行了小规模的横断面研究，以确定子宫内膜异位症患者的心理健康结果。需要进一步研究以全面评估子宫内膜异位症的心理健康后遗症。
