Tang Xin, Huang Gaoyangzi, Li Qifu, Zhao Siwen, Yang Ruqin, Wang Hongyang, Deng Yuanzheng, Liu Zili, Guo Taipin, Liang Fanrong
Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Chinese Medicine, Kunming, People's Republic of China.
School of Second Clinical Medicine/The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Nov 29;17:4573-4583. doi: 10.2147/DMSO.S487877. eCollection 2024.
Appetite plays a crucial role in obesity and weight loss outcomes. while conventional therapies reduce appetite, They often have limitations. Acupoint Catgut Embedding (ACE) is widely used for weight loss, but its impact on subjective appetite, especially across different appetite status, remains underexplored.
To evaluate the differential impact of ACE on the subjective appetite of overweight and obese adults with strong and moderate appetites.
This secondary analysis used data from a multicenter, double-blind, parallel randomized clinical trial of the ACE intervention. A total of 122 overweight and obese patients aged 18-60 were randomly assigned to the ACE and Non-acupoint Catgut Embedding (NACE) groups, each receiving six sessions over 12 weeks and a 4-week follow-up. Appetite was measured using the Visual Analogue Scale (VAS), and a generalized linear mixed-effects model assessed changes in appetite scores. Bonferroni corrections were applied for multiple comparisons ( < 0.05).
Participants with strong appetite in the ACE group showed a significant reduction in appetite VAS score from 7.78 (0.66) at baseline to 5.00 (0.72) at 16 weeks ( < 0.05), compared to a reduction from 7.97 (0.93) to 6.54 (1.17) in the NACE group. The adjusted relative rate ratio between the two groups was 0.411 (95% CI, 0.210 to 0.534; < 0.05). In participants with moderate appetite, no significant difference was observed between the two groups ( > 0.05). The significant baseline difference in appetite scores between participants with strong and moderate appetite ( < 0.05) became non-significant by week 16 ( > 0.05).
This study reveals the stratified effect of ACE on appetite, with greater reduction in those with strong appetite and no significant change in those with moderate appetite. This suggests ACE reduces appetite effectively without excessive suppression, supporting its potential as a sustainable obesity management strategy.
食欲在肥胖和减肥效果中起着关键作用。虽然传统疗法能降低食欲，但它们往往存在局限性。穴位埋线（ACE）被广泛用于减肥，但其对主观食欲的影响，尤其是在不同食欲状态下的影响，仍未得到充分研究。
评估穴位埋线对食欲较强和中等的超重及肥胖成年人主观食欲的差异影响。
本二次分析使用了穴位埋线干预的多中心、双盲、平行随机临床试验数据。共有122名年龄在18至60岁的超重和肥胖患者被随机分配到穴位埋线组和非穴位埋线（NACE）组，每组在12周内接受6次治疗，并进行4周的随访。使用视觉模拟量表（VAS）测量食欲，并采用广义线性混合效应模型评估食欲评分的变化。采用Bonferroni校正进行多重比较（<0.05）。
穴位埋线组中食欲较强的参与者的食欲VAS评分从基线时的7.78（0.66）显著降至16周时的5.00（0.72）（<0.05），而非穴位埋线组从7.97（0.93）降至6.54（1.17）。两组之间的调整相对率比为0.411（95%CI，0.210至0.534；<0.05）。在食欲中等的参与者中，两组之间未观察到显著差异（>0.05）。食欲较强和中等的参与者在基线时食欲评分的显著差异（<0.05）到第16周时变得不显著（>0.05）。
本研究揭示了穴位埋线对食欲的分层效应，食欲较强者降低幅度更大，食欲中等者无显著变化。这表明穴位埋线能有效降低食欲而不过度抑制，支持其作为可持续肥胖管理策略的潜力。
