医疗保健中的病原体基因组学：克服主动监测的障碍。

Sundermann Alexander J, Rosa Rossana, Harris Patrick N A, Snitkin Evan, Javaid Waleed, Moore Nicholas M, Hayden Mary K, Allen Krisandra, Rodino Kyle, Peacock Sharon J, Abbo Lilian M, Harrison Lee H

Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0147924. doi: 10.1128/aac.01479-24. Epub 2024 Dec 5.

Pathogen genomic surveillance in healthcare has the potential to enhance patient safety by detecting outbreaks earlier, thereby reducing morbidity and mortality. Despite benefits, there are barriers to adoption, including cost, expertise, and lack of standardized methodologies and incentives. This commentary advocates for 1) investment from healthcare payors, public health, and regulatory bodies and 2) additional research on genomic surveillance for improving patient outcomes and reducing infections. Effective implementation will require strategic investment and cross-sector collaboration.

医疗保健领域的病原体基因组监测有潜力通过更早地检测疫情来提高患者安全，从而降低发病率和死亡率。尽管有诸多益处，但在采用方面仍存在障碍，包括成本、专业知识以及缺乏标准化方法和激励措施。本评论主张：1）医疗保健支付方、公共卫生部门和监管机构进行投资；2）对基因组监测进行更多研究以改善患者治疗效果并减少感染。有效实施将需要战略投资和跨部门合作。