Kappel Dana, Gifford Hugh, Brackin Amelie, Abdolrasouli Alireza, Eyre David W, Jeffery Katie, Schlenz Silke, Aanensen David M, Brown Colin S, Borman Andrew, Johnson Elizabeth, Holmes Alison, Armstrong-James Darius, Fisher Matthew C, Rhodes Johanna
MRC Centre for Global Disease Analysis, Imperial College London, London, UK.
MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
NPJ Antimicrob Resist. 2024;2(1):26. doi: 10.1038/s44259-024-00043-6. Epub 2024 Sep 30.
is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug-resistant are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of to protect patients and healthcare services.
是一种在全球出现的真菌病原体，可引起医院内侵袭性感染。在此，我们使用前沿的基因组学方法来阐明英国境内耐药菌的时间和地理流行病学。我们分析了来自英国多家医院的200多个分离株的代表性样本，以评估引入的数量和时间，并推断唑类耐药分离株在医院间和医院内传播的后续模式。我们确定至少有一次来自进化枝I的引入和两次来自进化枝III的引入进入英国，并观察到医院之间抗真菌耐药分离株多次传播事件的时间和地理证据，以及确定了医院内患者之间的局部传播事件。我们的研究证实耐药菌的暴发是相关联的，并且患者之间会发生传播，这解释了当地医院的暴发情况，并表明需要加强对该菌的流行病学监测以保护患者和医疗服务。
