Yang Runhua, Ji Fen, Jiao Jianwei
Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China.
Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China.
Curr Opin Genet Dev. 2025 Feb;90:102286. doi: 10.1016/j.gde.2024.102286. Epub 2024 Dec 4.
The nervous system is the most complex system in the human body, and the normal development of the central nervous system (CNS) is essential for maintaining the healthy life activities of the individual. CNS development requires the orchestration of multiple internal or external or direct or indirect factors to regulate neural stem cell fate specification. Here, we provide a broad overview of the regulatory system of nerve cell fate decisions and discuss the latest technological approaches to achieve neural regeneration. Understanding the CNS development and regeneration mechanisms has shifted the paradigm from traditional experiments to high-throughput sequencing.
神经系统是人体中最复杂的系统，中枢神经系统（CNS）的正常发育对于维持个体的健康生命活动至关重要。中枢神经系统的发育需要多种内部或外部、直接或间接因素的协同作用来调节神经干细胞的命运决定。在此，我们对神经细胞命运决定的调节系统进行了广泛概述，并讨论了实现神经再生的最新技术方法。对中枢神经系统发育和再生机制的理解已将范式从传统实验转变为高通量测序。
