Peng Haiyang, Zhao Minjie, Zhang Yuezhou, Guo Yaoyuan, Zhao Andong
Department of Hepatobiliary Surgery, Second Hospital Affiliated to Chongqing Medical University, Chongqing, P. R. China.
Kuanren Laboratory of Translational lipidology, Centre for Lipid Research, Second Hospital, Chongqing Medical University, Chongqing, P. R. China.
Sci Rep. 2024 Dec 5;14(1):30386. doi: 10.1038/s41598-024-82203-2.
Serum magnesium cannot accurately assess magnesium deficiency. The association between magnesium deficiency and metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. Selecting 3,377 participants in the United States, we assessed the degree of magnesium deficiency in the population using magnesium depletion score (MDS). Multinomial logistic regression assessed the association between magnesium deficiency and MAFLD. Subgroup analyses assessed the association between dietary magnesium intake and MAFLD under different magnesium deficiency statuses. Structural equation modeling (SEM) revealed mediation effects. Magnesium deficiency was associated with MAFLD (ORseverevs.none: 1.69, 95%CI: 1.16-2.46; p for trend < 0.001). Magnesium intake was negatively associated with MAFLD only in the subgroup without magnesium deficiency (p for trend < 0.01). Inflammation, oxidative stress, and aging significantly mediated the association between MDS and MAFLD (all p < 0.05). In American adults, magnesium deficiency assessed by MDS might be a risk factor for MAFLD, with inflammation, oxidative stress, and aging potentially being key mechanisms. Simply increasing magnesium intake would not mitigate MAFLD risk associated with magnesium deficiency. Correcting magnesium deficiency might prevent MAFLD.
血清镁无法准确评估镁缺乏情况。镁缺乏与代谢功能障碍相关脂肪性肝病（MAFLD）之间的关联仍不明确。我们选取了美国的3377名参与者，使用镁耗竭评分（MDS）评估人群中的镁缺乏程度。多项逻辑回归分析评估镁缺乏与MAFLD之间的关联。亚组分析评估不同镁缺乏状态下膳食镁摄入量与MAFLD之间的关联。结构方程模型（SEM）揭示了中介效应。镁缺乏与MAFLD相关（重度缺乏vs无缺乏：OR = 1.69，95%CI：1.16 - 2.46；趋势p < 0.001）。仅在无镁缺乏的亚组中，镁摄入量与MAFLD呈负相关（趋势p < 0.01）。炎症、氧化应激和衰老显著介导了MDS与MAFLD之间的关联（所有p < 0.05）。在美国成年人中，通过MDS评估的镁缺乏可能是MAFLD的一个危险因素，炎症、氧化应激和衰老可能是关键机制。单纯增加镁摄入量并不能减轻与镁缺乏相关的MAFLD风险。纠正镁缺乏可能预防MAFLD。
