Sakai Kuniyoshi L
Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo.
Brain Nerve. 2024 Dec;76(12):1301-1306. doi: 10.11477/mf.1416202780.
The musician Ludwig van Beethoven suffered from progressive hearing loss and abdominal pain, both of which can be explained by lead intoxication. With genomic analyses, Begg et al. (2023) have confirmed that the five locks of hair attributed to Beethoven were authentic. Moreover, the possible cause of his severe liver disease was revealed. Rifai et al. (2024) have observed unusually high lead levels in authenticated locks of hair from Beethoven. Based on the new pieces of evidence, we conclude that his hearing loss and gastrointestinal complaints were caused by plumbism.
音乐家路德维希·凡·贝多芬患有渐进性听力损失和腹痛，这两者都可以用铅中毒来解释。通过基因组分析，贝格等人（2023年）证实了归因于贝多芬的五缕头发是真品。此外，还揭示了他严重肝病的可能病因。里法伊等人（2024年）在经鉴定的贝多芬头发样本中观察到异常高的铅含量。基于这些新证据，我们得出结论，他的听力损失和胃肠道不适是由铅中毒引起的。
