Chen Yang, Xiao Junfeng, Zhu Xiaoqing, Fan Xin, Peng Mingye, Mu Yang, Wang Chao, Xia Lusha, Zhou Mengzhou
Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, Hubei, 430068, China.
Department of gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430068, China.
Food Funct. 2025 Jan 2;16(1):147-167. doi: 10.1039/d4fo04911j.
Conjugated linoleic acid (CLA) is widely used as a dietary supplement due to its reported benefits in enhancing immunity, regulating inflammation, treating obesity, and preventing cancer. However, there is a lack of comprehensive studies on its mechanisms and dose-effect relationships. Moreover, there are insufficient in-depth studies on CLA's new functions, safety, side effects, and clinical utility. This review systematically examines the structure and sources of CLA, summarizes its role in improving human health, and critically reviews the potential mechanisms behind these benefits. It also analyzes the side effects of CLA and addresses issues related to dosing and oxidative decomposition in CLA research. Additionally, the potential of using CLA-producing probiotics to manage diseases is explored. This review can guide and promote further research on CLA's functions and support the development of CLA dietary supplements. It will accelerate the development of CLA nutritional and medical foods, contribute to the improvement of human health, and have important social meaning and economic value.
共轭亚油酸（CLA）因其在增强免疫力、调节炎症、治疗肥胖症和预防癌症方面的有益作用而被广泛用作膳食补充剂。然而，目前缺乏对其作用机制和剂量效应关系的全面研究。此外，对于CLA的新功能、安全性、副作用及临床应用也缺乏深入研究。本综述系统地研究了CLA的结构和来源，总结了其在改善人类健康方面的作用，并对这些益处背后的潜在机制进行了批判性综述。同时分析了CLA的副作用，并探讨了CLA研究中与剂量和氧化分解相关的问题。此外，还探索了使用产CLA益生菌来管理疾病的潜力。本综述可为CLA功能的进一步研究提供指导和促进作用，并支持CLA膳食补充剂的开发。它将加速CLA营养和医疗食品的发展，有助于改善人类健康，具有重要的社会意义和经济价值。
