Miller Christine M, Borre Carla, Green Alex, Funaro Melissa, Oliveira Carlos R, Iwasaki Akiko
Department of Pediatrics, Division of Infectious Diseases and Global Health, Yale University School of Medicine New Haven, New Haven, CT.
Harvey Cushing/John Hay Whitney Medical Library, Yale University, New Haven, CT.
Am J Med Open. 2024 Sep 26;12:100078. doi: 10.1016/j.ajmo.2024.100078. eCollection 2024 Dec.
A subset of children and adolescents experience recurrent or persistent symptoms following SARS-CoV-2 infection, known as postacute sequelae of COVID-19 (PASC), however, the clinical epidemiology within the United States (US) is not yet well understood. This scoping review aims to synthesize the clinical epidemiology of pediatric PASC in the US. A comprehensive literature search was conducted and databases were queried from inception until January 29, 2024. Studies including US children and adolescents <21 years old were considered. From 1028 studies identified, 29 met the inclusion criteria. Prevalence of PASC ranged from less than 1%-27%. Risk factors included older age, female sex, asthma, obesity, and severe initial infection. Common symptoms were dyspnea, fatigue, headaches, and chest pain. A multidisciplinary approach for diagnosis and management was common across studies. Most studies had a high risk of bias and were limited by a lack of standardized definitions and short follow-up duration. This review establishes a foundation for understanding pediatric PASC and highlights the critical need for continued research to optimize prevention and treatment strategies.
一部分儿童和青少年在感染新冠病毒2后会出现反复或持续的症状，即新冠后急性后遗症（PASC），然而，美国国内的临床流行病学情况尚未得到充分了解。本综述旨在综合美国儿童PASC的临床流行病学情况。我们进行了全面的文献检索，并查询了从数据库建立到2024年1月29日的资料。纳入的研究对象为美国21岁以下的儿童和青少年。在确定的1028项研究中，有29项符合纳入标准。PASC的患病率在不到1%至27%之间。风险因素包括年龄较大、女性、哮喘、肥胖和初始感染严重。常见症状有呼吸困难、疲劳、头痛和胸痛。跨研究普遍采用多学科方法进行诊断和管理。大多数研究存在较高的偏倚风险，且受限于缺乏标准化定义和随访时间短。本综述为理解儿童PASC奠定了基础，并强调了持续研究以优化预防和治疗策略的迫切需求。
