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橄榄油厂废水：从副产品到智能抗氧化材料。

Olive mill wastewater: From by-product to smart antioxidant material.

作者信息

Ruggeri Marco, De Luca Fabrizio, Ungolo Amedeo, Vigani Barbara, Paredes Alejandro J, Russo Eleonora, Bottone Maria Grazia, Bianchi Eleonora, Ferrari Franca, Rossi Silvia, Sandri Giuseppina

机构信息

Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy.

Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy.

出版信息

Int J Pharm X. 2024 Nov 7;8:100301. doi: 10.1016/j.ijpx.2024.100301. eCollection 2024 Dec.

DOI:10.1016/j.ijpx.2024.100301
PMID:39640079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11617292/
Abstract

Olive mill wastewater (OMWW) is a byproduct of olive oil extraction that represents a critical environmental concern due to its potential adverse effects on ecosystems. Given these premises, spray-dried microparticles were designed and developed using maltodextrins as carriers to encapsulate OMWW bioactive compounds. The microparticles were manufactured using an easily scalable and sustainable spray-drying process. The resulting microparticles were smooth, spherical, and exhibited a mean particle size of about 18 μm. The systems demonstrated notable antioxidant properties with a DPPH radical scavenging activity higher than 60 %, due to the polyphenolic compounds of OMWW (about 24 g gallic acid equivalents per g of sample). In addition, the microparticles supported fibroblast and macrophage viability at concentrations up to 1 mg/mL. They also determined a 4-fold inflammation reduction in macrophages, improved collagen expression in fibroblasts, and modulated oxidative stress on aged fibroblasts. In conclusion, these microparticles could be considered as promising medical devices in wound healing, while offering a sustainable solution for valorizing OMWW.

摘要

橄榄油厂废水（OMWW）是橄榄油提取过程中的副产品，因其对生态系统可能产生的不利影响而成为一个关键的环境问题。基于这些前提，以麦芽糊精为载体设计并开发了喷雾干燥微粒，用于封装OMWW生物活性化合物。这些微粒采用易于扩展且可持续的喷雾干燥工艺制造。所得微粒表面光滑、呈球形，平均粒径约为18μm。由于OMWW中的多酚类化合物（每克样品约含24克没食子酸当量），该系统表现出显著的抗氧化性能，DPPH自由基清除活性高于60%。此外，微粒在浓度高达1mg/mL时可支持成纤维细胞和巨噬细胞的活力。它们还使巨噬细胞中的炎症减少了4倍，改善了成纤维细胞中的胶原蛋白表达，并调节了衰老成纤维细胞的氧化应激。总之，这些微粒可被视为伤口愈合中有前景的医疗器械，同时为OMWW的增值提供了可持续的解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/0d1685cdfdb2/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/adbdda781a97/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ee5dc3f9c2b6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/be63f69baf56/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/1db1d1a3bb16/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ce4202ae53c8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ff5d3bbcab39/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/99bf7da0864c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ef27a8fad0a3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/0a49ed24daf6/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/0d1685cdfdb2/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/adbdda781a97/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ee5dc3f9c2b6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/be63f69baf56/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/1db1d1a3bb16/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ce4202ae53c8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ff5d3bbcab39/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/99bf7da0864c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/ef27a8fad0a3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/0a49ed24daf6/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0a3/11617292/0d1685cdfdb2/gr9.jpg

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2
Mycelium-based biomaterials as smart devices for skin wound healing.基于菌丝体的生物材料作为用于皮肤伤口愈合的智能装置。
Front Bioeng Biotechnol. 2023 Aug 15;11:1225722. doi: 10.3389/fbioe.2023.1225722. eCollection 2023.
3
Development of a novel in-situ aluminum/carbon composite from olive mill wastewater for the selective adsorption and separation of malachite green and acid yellow 61.
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Bioresour Technol. 2023 Sep;384:129272. doi: 10.1016/j.biortech.2023.129272. Epub 2023 Jun 7.
4
Voghera Sweet Pepper: A Potential Ally against Oxidative Stress and Aging.沃格拉甜椒：对抗氧化应激和衰老的潜在盟友。
Int J Mol Sci. 2023 Feb 14;24(4):3782. doi: 10.3390/ijms24043782.
5
Towards a circular economy in virgin olive oil production: Valorization of the olive mill waste (OMW) "alpeorujo" through polyphenol recovery with natural deep eutectic solvents (NADESs) and vermicomposting.迈向初榨橄榄油生产中的循环经济：通过使用天然低共熔溶剂（NADESs）回收多酚和进行蚯蚓堆肥实现橄榄果渣“alpeorujo”的价值提升。
Sci Total Environ. 2023 May 10;872:162198. doi: 10.1016/j.scitotenv.2023.162198. Epub 2023 Feb 13.
6
Treatment technologies for olive mill wastewater with impacts on plants.对植物有影响的橄榄油厂废水处理技术。
Environ Res. 2023 Jan 1;216(Pt 3):114399. doi: 10.1016/j.envres.2022.114399. Epub 2022 Oct 27.
7
Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering.用于解决皮肤组织工程中细菌感染问题的智能纳米微颗粒
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8
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Biomater Adv. 2022 Feb;133:112593. doi: 10.1016/j.msec.2021.112593. Epub 2021 Dec 3.
10
Nitric oxide-releasing biomaterials for promoting wound healing in impaired diabetic wounds: State of the art and recent trends.用于促进受损糖尿病伤口愈合的一氧化氮释放生物材料：现状与最新趋势
Biomed Pharmacother. 2022 May;149:112707. doi: 10.1016/j.biopha.2022.112707. Epub 2022 Mar 15.