脱水羊膜贴片用于治疗继发于 mirvetuximab soravtansine-gynx（MIRV）治疗的眼部事件。
Dehydrated amniotic membrane patch for the treatment of an ocular event secondary to mirvetuximab soravtansine-gynx (MIRV) therapy.
作者信息
File Brittany, Hari Anjali, Bei Ling
机构信息
Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange, CA, USA.
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of California, Irvine Medical Center, Orange, CA, USA.
出版信息
Gynecol Oncol Rep. 2024 Nov 19;56:101547. doi: 10.1016/j.gore.2024.101547. eCollection 2024 Dec.
Abstract
•Mirvetuximab soravtansine (MIRV) is used in the treatment of FRα positive, platinum-resistant epithelial ovarian cancer.•MIRV is associated with ocular events, leading to dose delays, dose reductions, and discontinuations of chemotherapy.•Mitigation strategies to prevent treatment disruption have historically relied on corticosteroid and lubricating drops.•Dehydrated amniotic membrane patch to treat MIRV related ocular events is a novel therapeutic option.
摘要
• mirvetuximab soravtansine（MIRV）用于治疗FRα阳性、铂耐药的上皮性卵巢癌。
• MIRV与眼部事件相关，导致化疗剂量延迟、剂量减少和中断。
• 历史上，预防治疗中断的缓解策略依赖于皮质类固醇和润滑滴眼液。
• 脱水羊膜贴片治疗MIRV相关眼部事件是一种新的治疗选择。
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